5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Base Information

Chemical Name:5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.:284490-15-9
Molecular Formula:C26H45N3O7Si
Molecular Weight:539.745
Hs Code.:
Mol file:284490-15-9.mol

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Synonyms:5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

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Chemical Property of 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

Chemical Property:

Boiling Point:602.1±55.0 °C(Predicted)
PKA:15.65±0.50(Predicted)
PSA：125.34000
Density:1.117±0.06 g/cm3(Predicted)
LogP:5.49500

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-

There total 21 articles about 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 222631-12-1
1-benzyl 2-ethyl 3-amino-4-((3aS,4S,6R,6aR)-5-(tert-butoxycarbonyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo [4,5-c]pyrrol-4-yl)-1H-pyrrole-1,2-dicarboxylate

: 284490-15-9
(3aS,4S,6R,6aR)-tert-butyl 4-(4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h;
DOI:10.1016/S0040-4020(00)00194-0

Reference yield:

: 153172-31-7
(3aR,4R,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole

: 284490-15-9
(3aS,4S,6R,6aR)-tert-butyl 4-(4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: NCS / pentane / 1 h

1.2: LiTMP / tetrahydrofuran / -78 °C

2.1: 0.83 g / tetrahydrofuran / 1 h / -78 °C

3.1: 85 percent / CH₂Cl₂ / 16 h / 20 °C

4.1: dimethylformamide / 1 h / 65 - 70 °C

5.1: 0.68 g / aq. AcOH / tetrahydrofuran / 1.5 h / 20 °C

6.1: 3.46 g / NaOAc / methanol / 16 h / 20 °C

7.1: 3.68 g / DBU / CH₂Cl₂ / 4 h / Heating

8.1: 0.12 g / H₂ / Pd/C / ethanol / 3 h

With N-chloro-succinimide; hydrogen; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; pentane; 1.1: Chlorination / 1.2: Elimination / 2.1: Addition / 3.1: Substitution / 4.1: Condensation / 5.1: Hydrolysis / 6.1: Condensation / 7.1: Substitution / 8.1: Hydrogenolysis;
DOI:10.1016/S0040-4020(00)00194-0

Reference yield:

: 222631-08-5
2-((3aS,4S,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo [4,5-c]pyrrol-4-yl)acetonitrile

: 284490-15-9
(3aS,4S,6R,6aR)-tert-butyl 4-(4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / CH₂Cl₂ / 16 h / 20 °C

2: dimethylformamide / 1 h / 65 - 70 °C

3: 0.68 g / aq. AcOH / tetrahydrofuran / 1.5 h / 20 °C

4: 3.46 g / NaOAc / methanol / 16 h / 20 °C

5: 3.68 g / DBU / CH₂Cl₂ / 4 h / Heating

6: 0.12 g / H₂ / Pd/C / ethanol / 3 h

With hydrogen; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation / 3: Hydrolysis / 4: Condensation / 5: Substitution / 6: Hydrogenolysis;
DOI:10.1016/S0040-4020(00)00194-0