2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline

Base Information

• Chemical Name: 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline
• CAS No.: 342621-21-0
• Molecular Formula: C₁₇H₂₅ClF₃NO₂Si
• Molecular Weight: 395.925
• Mol file: 342621-21-0.mol

Synonyms:2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline;1-[2-AMino-5-chloro-4-(triisopropylsilyloxy)phenyl]-2,2,2-trifluoroethanone;1-[2-AMino-5-chloro-4-[[tris(1-Methylethyl)silyl]oxy]phenyl] -2,2,2-trifluoroethanone

Chemical Property of 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 418.627°C at 760 mmHg
• Flash Point: 206.979°C
• PSA: 52.32000
• Density: 1.149g/cm³
• LogP: 6.80270
• Solubility.: Dichloromethane, Ethyl Acetate, Hexane

Purity/Quality:

97% ^*data from raw suppliers

2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline (cas# 342621-21-0) is a compound useful in organic synthesis.

Technology Process of 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline

There total 6 articles about 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-nitroanisole (1009-36-5) → 1-(2-amino-5-chloro-4-triisopropylsilanyloxy-phenyl)-2,2,2-trifluoro-ethanone (342621-21-0)

Guidance literature:

Multi-step reaction with 7 steps

1: BBr₃ / CH₂Cl₂

2: imidazole / dimethylformamide

3: H₂ / Pd/C / ethyl acetate

4: Et₃N / CH₂Cl₂

5: s-BuLi / diethyl ether / 0 - 20 °C

6: aq. HCl / 1,2-dimethoxy-ethane

7: imidazole / dimethylformamide

With 1H-imidazole; hydrogenchloride; hydrogen; sec.-butyllithium; boron tribromide; triethylamine; palladium on activated charcoal; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00012-9

Reference yield:

5-nitro-2-chlorophenol (619-10-3) → 1-(2-amino-5-chloro-4-triisopropylsilanyloxy-phenyl)-2,2,2-trifluoro-ethanone (342621-21-0)

Guidance literature:

Multi-step reaction with 6 steps

1: imidazole / dimethylformamide

2: H₂ / Pd/C / ethyl acetate

3: Et₃N / CH₂Cl₂

4: s-BuLi / diethyl ether / 0 - 20 °C

5: aq. HCl / 1,2-dimethoxy-ethane

6: imidazole / dimethylformamide

With 1H-imidazole; hydrogenchloride; hydrogen; sec.-butyllithium; triethylamine; palladium on activated charcoal; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00012-9

Reference yield:

(2-chloro-5-nitro-phenoxy)-triisopropyl-silane → 1-(2-amino-5-chloro-4-triisopropylsilanyloxy-phenyl)-2,2,2-trifluoro-ethanone (342621-21-0)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Pd/C / ethyl acetate

2: Et₃N / CH₂Cl₂

3: s-BuLi / diethyl ether / 0 - 20 °C

4: aq. HCl / 1,2-dimethoxy-ethane

5: imidazole / dimethylformamide

With 1H-imidazole; hydrogenchloride; hydrogen; sec.-butyllithium; triethylamine; palladium on activated charcoal; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00012-9

upstream raw materials:

2-chloro-5-nitroanisole

5-nitro-2-chlorophenol

4-chloro-3-triisopropylsilanyloxy-phenylamine

N-(4-chloro-3-triisopropylsilanyloxy-phenyl)-2,2-dimethyl-propionamide

Refernces