619-10-3Relevant articles and documents
Effect of chloride ion concentration on rapid kinetics of chlorination of regioisomers of nitrophenol by molecular chlorine in aqueous medium using rotating platinum electrode
Sukul,Bonde,Bhadane,Dangat
, p. 2159 - 2163 (2016/02/27)
The rapid kinetics of chlorination of regioisomers of the nitrophenol by molecular chlorine in the presence of chloride ion in aqueous solution has been studied using rotating platinum electrode (RPE). The chloride ion has a catalytic effect on the chlorination reaction. The mechanism suggested explaining the catalytic effect of chloride ion postulates a longer mean life for Cl-Cl dipole induced by the aromatic substrate by electron rearrangement with the chloride ion, which facilitate the electrophilic attack of Cl-Cl on the aromatic substrate in rate determining step. Hence the specific reaction rate varies linearly with the concentration of chloride ion.
Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs
Rai, Diwakar,Chen, Wenmin,Tian, Ye,Chen, Xuwang,Zhan, Peng,De Clercq, Erik,Pannecouque, Christophe,Balzarini, Jan,Liu, Xinyong
, p. 7398 - 7405 (2013/11/19)
A novel series of 3-benzyloxy-linked pyrimidinylphenylamine derivatives (8a-8s) was designed, synthesized and evaluated for their in vitro anti-HIV activity in MT-4 cell cultures. Most of the compounds inhibited wild-type (wt) HIV-1 replication in the lower micromolar concentration range (EC50 = 0.05-35 μM) with high selectivity index (SI) values (ranged from 10 to >4870). In particular, 8h and 8g displayed excellent antiretroviral activity against wt HIV-1 with low cytotoxicity (EC50 = 0.07 μM, CC 50 >347 μM, SI >4870; EC50 = 0.05 μM, CC 50 = 42 μM, SI = 777, respectively), comparable to that of the marked drug nevirapine (EC50 = 0.113 μM, CC50 >15 μM, SI >133). In order to confirm the binding target, 8h was selected to perform the anti-HIV-1 RT assay. Additionally, preliminary structure activity relationship (SAR) analysis and molecular docking studies of newly synthesized compounds were also discussed, as well as the predicted physicochemical properties.
COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION
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Page/Page column 34; 35, (2012/02/02)
Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (β-AP) production.
