Tert-butyl 4-(4-fluoro-2-formylphenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 4-(4-fluoro-2-formylphenyl)piperazine-1-carboxylate
• CAS No.: 697305-53-6
• Molecular Formula: C16H21FN2O3
• Molecular Weight: 308.353
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID20470544
• Wikidata: Q82298658
• Mol file: 697305-53-6.mol

Synonyms:697305-53-6;2-(4-Boc-piperazino-1-yl)-5-fluorobenzaldehyde;tert-butyl 4-(4-fluoro-2-formylphenyl)piperazine-1-carboxylate;SCHEMBL5913105;DTXSID20470544;CUQLHUZVZHDBHN-UHFFFAOYSA-N;FT-0679676

Chemical Property of Tert-butyl 4-(4-fluoro-2-formylphenyl)piperazine-1-carboxylate

Chemical Property:

• PSA: 49.85000
• LogP: 2.69820
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 308.15362070
• Heavy Atom Count: 22
• Complexity: 403

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Boc-piperazino-1-yl)-5-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCN(CC1)C2=C(C=C(C=C2)F)C=O

Technology Process of Tert-butyl 4-(4-fluoro-2-formylphenyl)piperazine-1-carboxylate

There total 6 articles about Tert-butyl 4-(4-fluoro-2-formylphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

tert-butyl 4-(4-fluoro-2-(hydroxymethyl)phenyl)piperazine-1-carboxylate → 4-(4-fluoro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (697305-53-6)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 96h;

Reference yield: 52.0%

tert-butyl 4-(2-bromo-4-fluorophenyl)piperazine-1-carboxylate (697305-52-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-(4-fluoro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (697305-53-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.16667h;

Reference yield: 32.0%

2,5-difluorobenzaldehyde (2646-90-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(4-fluoro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (697305-53-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 18h;

DOI:10.1021/jo051514p

upstream raw materials:

2,5-difluorobenzaldehyde

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(2-bromo-4-fluorophenyl)piperazine-1-carboxylate

N,N-dimethyl-formamide

Downstream raw materials:

4-{4-fluoro-2-[((R_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

4-{4-fluoro-2-[((S_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

2-methyl-propane-2-sulfinic acid [2-ethoxy-1-(5-fluoro-2-piperazin-1-yl-phenyl)-ethyl]-amide

2-Methyl-propane-2-sulfinic acid [(S)-1-(5-fluoro-2-piperazin-1-yl-phenyl)-3-methyl-butyl]-amide