4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 886366-42-3
• Molecular Formula: C13H13NO3S
• Molecular Weight: 263.317
• Hs Code.: 2934100090
• Mol file: 886366-42-3.mol

Synonyms:ethylmethoxyphenylthiazolecarboxylate;Ethyl 4-(4-methoxyphenyl)thiazole-2-carboxylate;

Chemical Property of 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 76.66000
• LogP: 2.99540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4-(4-methoxyphenyl)-1,3-thiazole-2-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

There total 1 articles about 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 2-amino-2-thioxoacetate (16982-21-1) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → ethyl 4-(4-methoxyphenyl)thiazole-2-carboxylate (886366-42-3)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1016/j.bioorg.2019.103254

Reference yield: 76.0%

ethyl 4-(4-methoxyphenyl)thiazole-2-carboxylate (886366-42-3) → 2-(chloromethyl)-4-(4-methoxyphenyl)thiazole

Guidance literature:

ethyl 4-(4-methoxyphenyl)thiazole-2-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 0.5h; Reflux;

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 40 ℃; for 4h;

DOI:10.1016/j.bioorg.2019.103254

Reference yield: 71.0%

ethyl 4-(4-methoxyphenyl)thiazole-2-carboxylate (886366-42-3) → 4-(4-methoxyphenyl)thiazole-2-carbohydrazide

Guidance literature:

With hydrazine hydrate; In methanol; for 3h; Reflux;

DOI:10.1016/j.bmc.2022.116609

upstream raw materials:

ethyl 2-amino-2-thioxoacetate

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

4-(4-methoxyphenyl)thiazole-2-carboxylic acid

4-(4-methoxy-phenyl)-thiazole

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