4-(4-Methoxyphenyl)-1,3-thiazole

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)-1,3-thiazole
• CAS No.: 1826-21-7
• Molecular Formula: C10H9NOS
• Molecular Weight: 191.254
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID70398668
• Wikidata: Q82200777
• Mol file: 1826-21-7.mol

Synonyms:1826-21-7;4-(4-methoxyphenyl)-1,3-thiazole;4-(4-methoxyphenyl)thiazole;4-(4-METHOXY-PHENYL)-THIAZOLE;Thiazole, 4-(4-methoxyphenyl)-;SCHEMBL4516813;DTXSID70398668;BBL020543;STK893232;AKOS001476050;CS-0336728

Chemical Property of 4-(4-Methoxyphenyl)-1,3-thiazole

Chemical Property:

• PSA: 50.36000
• LogP: 2.81870
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.04048508
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(4-Methoxyphenyl)-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CSC=N2

Technology Process of 4-(4-Methoxyphenyl)-1,3-thiazole

There total 6 articles about 4-(4-Methoxyphenyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C23H19NO2S → 4-(4-methoxy-phenyl)-thiazole (1826-21-7)

Guidance literature:

With caesium carbonate; In m-xylene; at 150 ℃; for 40h; regioselective reaction;

DOI:10.1039/c3sc52199k

Reference yield:

ethyl 4-(4-methoxyphenyl)thiazole-2-carboxylate (886366-42-3) → 4-(4-methoxy-phenyl)-thiazole (1826-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 20 °C

2: hydrogenchloride / 1,4-dioxane; water / Reflux

With hydrogenchloride; water; sodium hydroxide; In 1,4-dioxane; ethanol; water;

DOI:10.1016/j.bmcl.2012.09.099

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 4-(4-methoxy-phenyl)-thiazole (1826-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / Reflux

2: sodium hydroxide; water / ethanol / 20 °C

3: hydrogenchloride / 1,4-dioxane; water / Reflux

With hydrogenchloride; water; sodium hydroxide; In 1,4-dioxane; ethanol; water;

DOI:10.1016/j.bmcl.2012.09.099

upstream raw materials:

2-Bromo-4'-methoxyacetophenone

ethyl 4-(4-methoxyphenyl)thiazole-2-carboxylate

4-(4-methoxyphenyl)thiazole-2-carboxylic acid

4-methoxyphenylboronic acid

Downstream raw materials:

4-(4′-methoxyphenyl)-2-phenylthiazole

2-(methylthio)-4-phenylthiazole