Valbenazine

Base Information

Chemical Name:Valbenazine
CAS No.:1025504-45-3
Molecular Formula:C24H38N2O4
Molecular Weight:418.577
Hs Code.:
Mol file:1025504-45-3.mol

Synonyms:Valbenazine

Suppliers and Price of Valbenazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Valbenazine(~90%Purity)
25mg
$ 770.00

Medical Isotopes, Inc.
Valbenazine
5 mg
$ 490.00

Medical Isotopes, Inc.
Valbenazine
2.5 mg
$ 380.00

DC Chemicals
Valbenazine（NBI-98854） >98%
250 mg
$ 1300.00

DC Chemicals
Valbenazine（NBI-98854） >98%
100 mg
$ 700.00

Crysdot
Valbenazine 95+%
5mg
$ 84.00

Crysdot
Valbenazine 95+%
10mg
$ 154.00

ChemScene
Valbenazine 99.03%
100mg
$ 1440.00

ChemScene
Valbenazine 99.03%
10mg
$ 252.00

ChemScene
Valbenazine 99.03%
25mg
$ 540.00

Total 40 raw suppliers

Chemical Property of Valbenazine

Chemical Property:

Boiling Point:507.2±50.0 °C(Predicted)
PKA:7.76±0.33(Predicted)
PSA：74.02000
Density:1.11±0.1 g/cm3(Predicted)
LogP:4.20230
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Valbenazine(~90%Purity) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Valbenzine is a highly selective vesicular monoamine transporter 2 inhibitor. It is used in the treatment of tardive dykinesia.

Technology Process of Valbenazine

There total 4 articles about Valbenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1025504-76-0
(S)-2-benzyloxycarbonyl-amino-3-methylbutyric acid-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester

: 1025504-45-3
(S)-2-amino-3-methylbutyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolizin-2-yl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: (2R,3R,11bR)-dihydrotetrabenazine

: 1025504-45-3
(S)-2-amino-3-methylbutyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolizin-2-yl ester

Guidance literature:: (S)-N-(benzyloxycarbonyl)valine; (2R,3R,11bR)-dihydrotetrabenazine; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h;

With palladium on activated charcoal; hydrogen; In methanol; for 2h;

Reference yield:

: 58-46-8,1381929-92-5
(3R^*,11bR^*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo quinolizin-2-one

: 1025504-45-3
(S)-2-amino-3-methylbutyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolizin-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1S)-10-camphorsulfonic acid / acetone / 24 h / 16 - 31 °C

1.2: pH 8

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / -20 °C

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane

4.1: palladium on activated charcoal; hydrogen / methanol / Inert atmosphere

With dmap; dimethylsulfide borane complex; palladium on activated charcoal; (1S)-10-camphorsulfonic acid; hydrogen; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; acetone;