NMS 873

Base Information

Chemical Name:NMS 873
CAS No.:1418013-75-8
Molecular Formula:C₂₇H₂₈N₄O₃S₂
Molecular Weight:520.676
Hs Code.:
Mol file:1418013-75-8.mol

Synonyms:NMS 873;NMS873;NMS-873;NMS873/NMS-873;Pyridine, 3-[3-(cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-;3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine NMS-873;NMS 873 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine;3-[3-Cyclopentylsulfanyl-5-(4′-methanesulfonyl-2-methylbiphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine

Suppliers and Price of NMS 873

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NMS-873
25mg
$ 300.00

Tocris
NMS873 ≥98%(HPLC)
25
$ 364.00

Tocris
NMS873 ≥98%(HPLC)
5
$ 96.00

Sigma-Aldrich
VCP Inhibitor III, NMS-873 - CAS 1418013-75-8 - Calbiochem
10 mg
$ 211.00

Sigma-Aldrich
VCP Inhibitor III, NMS-873 - CAS 1418013-75-8 - Calbiochem
5310880001
$ 203.00

Sigma-Aldrich
NMS-873 ≥98% (HPLC)
5mg
$ 131.00

Sigma-Aldrich
NMS-873 ≥98% (HPLC)
25mg
$ 497.00

Medical Isotopes, Inc.
NMS-873
5 mg
$ 610.00

DC Chemicals
NMS-873 >99%
100 mg
$ 500.00

DC Chemicals
NMS-873 >99%
250 mg
$ 950.00

Total 31 raw suppliers

Chemical Property of NMS 873

Chemical Property:

Boiling Point:769.3±70.0 °C(Predicted)
PKA:2.48±0.12(Predicted)
PSA：120.65000
Density:1.33±0.1 g/cm3(Predicted)
LogP:6.73570
Storage Temp.:2-8°C
Solubility.:DMSO: soluble25mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

NMS-873 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Description The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.
Uses NMS-873 is a potent and specific VCP inhibitor, which has shown to activate the unfolded protein response, interfere with autophagy and induce cancer cell death.

Technology Process of NMS 873

There total 7 articles about NMS 873 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1418013-41-8
C₂₀H₂₁BrN₄OS

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1418013-75-8
NMS-873

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h; Microwave irradiation; Inert atmosphere;
DOI:10.1021/jm3013213

Reference yield:

: 1418012-77-7
3-(3-benzyloxymethyl-5-cyclopentylsulfanyl[1,2,4]triazol-4-yl)pyridine

: 1418013-75-8
NMS-873

Guidance literature:: Multi-step reaction with 4 steps

1: boron trichloride / dichloromethane / 2 h / 0 - 5 °C

2: thionyl chloride / dichloromethane / 2 h / 0 - 5 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

4: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 3 h / 100 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron trichloride; potassium carbonate; caesium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4: |Suzuki Coupling;
DOI:10.1021/jm3013213

Reference yield:

: 1418012-79-9
3-(3-chloromethyl-5-cyclopentylsulfanyl[1,2,4]triazol-4-yl)pyridine

: 1418013-75-8
NMS-873

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 3 h / 100 °C / Microwave irradiation; Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1021/jm3013213