Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)-

Base Information

Chemical Name:Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)-
CAS No.:1383982-64-6
Molecular Formula:C26H28N4O
Molecular Weight:412.535
Hs Code.:
Mol file:1383982-64-6.mol

Synonyms:Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)-;AZD3293

Suppliers and Price of Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Lanabecestat(AZD3293,LY-3314814) >98%
100 mg
$ 1200.00

DC Chemicals
Lanabecestat(AZD3293,LY-3314814) >98%
1 g
$ 4100.00

DC Chemicals
Lanabecestat(AZD3293,LY-3314814) >98%
250 mg
$ 2100.00

ChemScene
Lanabecestat 99.76%
100mg
$ 1750.00

ChemScene
Lanabecestat 99.76%
50mg
$ 1100.00

ChemScene
Lanabecestat 99.76%
10mg
$ 390.00

ChemScene
Lanabecestat 99.76%
5mg
$ 250.00

ChemScene
Lanabecestat 99.76%
2mg
$ 140.00

Total 22 raw suppliers

Chemical Property of Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)-

Chemical Property:

Boiling Point:621.9±65.0 °C(Predicted)
PKA:4.60±0.60(Predicted)
PSA：72.86000
Density:1.23±0.1 g/cm3(Predicted)
LogP:3.80750

Purity/Quality:

99%, ^*data from raw suppliers

Lanabecestat(AZD3293,LY-3314814) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)-

There total 32 articles about Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (1r,1’R,4R)-6’-bromo-4-methoxy-5''-methyl-3’H-dispiro[cyclohexane-1,2'-indene-1’2”-imidazol]-4”-amine D(+)-10-camphorsulfonic acid salt

: 2-(5-(prop-1-ynyl)pyridin-3-yl)-1,3,6,2-dioxazaborocane

: 1383982-64-6
(1r,1’R,4R)-4-methoxy-5”-methyl-6’-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2’-indene-1’2”-imidazol]-4”-amine

Guidance literature:: With potassium phosphate; dichloro bis((p-dimethylaminophenyl)-?-di-tert-butylphosphine)palladium(II); In ethanol; water; at 80 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/acs.oprd.8b00312

Reference yield: 43.0%

: 917471-30-8
5-(prop-1-ynyl)pyridin-3-ylboronic acid

: 1384082-50-1
(1r,1'R,4R)-6'-bromo-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazole]-4-amine

: 1383982-64-6
(1r,1’R,4R)-4-methoxy-5”-methyl-6’-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2’-indene-1’2”-imidazol]-4”-amine

Guidance literature:: With potassium carbonate; sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; In 2-methyltetrahydrofuran; water; at 80 ℃; Inert atmosphere;