trans-4-AMino-4-Methylcyclohexanol hydrochloride

Base Information

• Chemical Name: trans-4-AMino-4-Methylcyclohexanol hydrochloride
• CAS No.: 1447955-52-3
• Molecular Formula: C₇H₁₅NO*ClH
• Molecular Weight: 165.663
• Mol file: 1447955-52-3.mol

Synonyms:trans-4-AMino-4-Methylcyclohexanol hydrochloride

Chemical Property of trans-4-AMino-4-Methylcyclohexanol hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

trans-4-Amino-4-methylcyclohexanolhydrochloride 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-AMino-4-Methylcyclohexanol hydrochloride

There total 1 articles about trans-4-AMino-4-Methylcyclohexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-(1-methyl-4-oxo-cyclohexyl)carbamate (412293-43-7) → 4-amino-4-methylcyclohexan-1-ol hydrochloride (1447955-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / 2 h / 20 °C

2: hydrogenchloride / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; In ethyl acetate;

Reference yield:

4-amino-4-methylcyclohexan-1-ol hydrochloride (1447955-52-3) → 2-chloro-9-(4-hydroxy-1-methylcyclohexyl)-7,9-dihydro-8H-purin-8- one

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 0 - 25 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 5 h / 0 - 25 °C / Inert atmosphere

3: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 48 h / 80 °C / Inert atmosphere

With diphenyl phosphoryl azide; water; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

4-amino-4-methylcyclohexan-1-ol hydrochloride (1447955-52-3) → 2-chloro-9-((1s,4s)-4-hydroxy-1-methylcyclohexyl)-7-methyl-7,9-dihydro-8H-purin-8-one

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 0 - 25 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 5 h / 0 - 25 °C / Inert atmosphere

3: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 48 h / 80 °C / Inert atmosphere

4: sodium hydroxide; tetrabutylammomium bromide / water; dichloromethane / 16 h / 17 - 25 °C / Inert atmosphere

With diphenyl phosphoryl azide; tetrabutylammomium bromide; water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;

upstream raw materials:

tert-butyl N-(1-methyl-4-oxo-cyclohexyl)carbamate

Refernces