6-Chloro-2-(4-tert-butoxycarbonylpiperazino) -4-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 6-Chloro-2-(4-tert-butoxycarbonylpiperazino) -4-(trifluoromethyl)pyridine
• CAS No.: 1201675-03-7
• Molecular Formula: C15H19ClF3N3O2
• Molecular Weight: 365.7784696
• Hs Code.: 2933399990
• Mol file: 1201675-03-7.mol

Synonyms:6-Chloro-2-(4-tert-butoxycarbonylpiperazino) -4-(trifluoromethyl)pyridine;6-Chloro-2-(4-tert-butoxycarbonylpiperazin-1-yl)-4-(trifluoromethyl)pyridine

Chemical Property of 6-Chloro-2-(4-tert-butoxycarbonylpiperazino) -4-(trifluoromethyl)pyridine

Chemical Property:

• Boiling Point: 443.7±45.0 °C(Predicted)
• PKA: 3.28±0.10(Predicted)
• PSA: 45.67000
• Density: 1.312±0.06 g/cm3(Predicted)
• LogP: 3.81380

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl4-[6-Chloro-4-(trifluoromethyl)-2-pyridyl]piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 6-Chloro-2-(4-tert-butoxycarbonylpiperazino) -4-(trifluoromethyl)pyridine

There total 2 articles about 6-Chloro-2-(4-tert-butoxycarbonylpiperazino) -4-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-4-(trifluoromethyl)pyridine (39890-98-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(6-chloro-4-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (1201675-03-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 90 ℃; for 48h; Sealed tube;

DOI:10.1021/jm100076w

Reference yield:

→ 4-(6-chloro-4-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (1201675-03-7)

Guidance literature:

Reference yield:

2-cyclohexylamino-4-iodopyridine (1201674-99-8) + 4-(6-chloro-4-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (1201675-03-7) → 6-(4-tert-butoxycarbonylpiperazin-1-yl)-2'-cyclohexylamino-[2,4']bipyridinyl-4-trifluoromethane (1201673-41-7)

Guidance literature:

2-cyclohexylamino-4-iodopyridine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane; In toluene; at 100 ℃; Inert atmosphere;

4-(6-chloro-4-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester; With bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride; In 1,4-dioxane; at 100 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm100076w

upstream raw materials:

2,6-dichloro-4-(trifluoromethyl)pyridine

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

6-(4-tert-butoxycarbonylpiperazin-1-yl)-2'-cyclohexylamino-[2,4']bipyridinyl-4-trifluoromethane

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