39890-98-7

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dichloro-4-(trifluoromethyl)pyridine is used as a key intermediate in the synthesis of pharmaceutical agents for its potential antitumor activities. Its unique structural features allow for the development of compounds that can target and inhibit specific molecular pathways involved in tumor growth and progression, offering a promising avenue for the creation of novel cancer therapeutics.

InChI:InChI=1/C6H4FNO/c7-6-1-5(4-9)2-8-3-6/h1-4H

Upstream product

• 4162-55-4 3-(trifluoromethyl)pentanedioic acid 
• 4759-65-3 3-(trifluoromethyl)glutaric anhydride 
• 36610-32-9 4-hydroxy-4-trifluoromethyl-1,6-heptadiene 
• 356518-29-1 4-trifluoromethyl-2,6-piperidinedione 
• 339539-97-8 4-trifluoromethyl-3H-pyridine-2,6-dione 
• 339539-96-7 3-hydroxy-3-trifluoromethyl-1,5-pentanedialdehyde 
• 36610-31-8 3-hydroxy-3-trifluoromethyl-1,5-pentanedicarboxylic acid 

Downstream Products

• 326894-74-0 2-iodo-4-(trifluoromethyl)pyridine 
• 100366-76-5 2,6-diiodo-4-(trifluoromethyl)pyridine 
• 862120-74-9 2-(2-nitrophenyl)sulfonyl-8-(trifluoromethyl)-3,4-dihydro-1H-pyrido[1,2-a]pyrazin-6-one 
• 862120-73-8 N-(2-bromoethyl)-2-nitro-N-[[6-oxo-4-(trifluoromethyl)-1H-pyridin-2-yl]methyl]benzenesulfonamide 
• 862120-72-7 N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide 
• 1160994-99-9 2-chloro-6-methoxy-4-(trifluoromethyl)pyridine 
• 165385-89-7 6-methyl-4-(trifluoromethyl)pyridin-2-amine 

Relevant academic research and scientific papers

SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY

Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.

Compounds with anti-cancer activity

Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

Convenient approaches to 4-trifluoromethylpyridine

A number of approaches to the synthesis of 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine are described. The first method for 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2,6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-trifluoromethylpyridine is prepared from ethyl(trifluoroacetylvinyl)ether in two steps.

Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3′-(N-tosyl-6′-methoxyl-indolyl)] pyridine was identified as the most potent in this series.

Synthesis of novel analogues of marine indole alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines as potential anticancer agents

Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines were synthesized using Suzuki cross-coupling reaction between 2-chloro-4-trifluoromethylpyridine 9, 2,6-dichloro-4-trifluoromethylpyridine 6 or 2,6-dichloro-3-cyano-4-tri