1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylic acid

Base Information

Chemical Name:1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylic acid
CAS No.:446829-40-9
Molecular Formula:C₁₂H₁₁NO₂
Molecular Weight:201.225
Hs Code.:
ChEMBL ID:CHEMBL5010045
DSSTox Substance ID:DTXSID20406383
Mol file:446829-40-9.mol

Synonyms:1,2,3,4-tetrahydrocyclopenta[b]indole-7-carboxylic acid;446829-40-9;Oprea1_094805;SCHEMBL4283723;CHEMBL5010045;DTXSID20406383;CYCLOPENT[B]INDOLE-7-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO;AKOS000295370;FT-0690795;AQ-086/40975344;Cyclopent[b]indole-7-carboxylic acid 1,2,3,4-tetrahydro;Cyclopent[b]indole-7-carboxylic acid,1,2,3,4-tetrahydro

Suppliers and Price of 1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylicacid 97%
1g
$ 541.00

American Custom Chemicals Corporation
1,2,3,4-TETRAHYDROCYCLOPENT[B]INDOLE-7-CARBOXYLIC ACID 95.00%
5MG
$ 503.66

Alichem
1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylicacid
1g
$ 454.23

Total 3 raw suppliers

Chemical Property of 1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylic acid

Chemical Property:

PSA：53.09000
LogP:2.35480
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:201.078978594
Heavy Atom Count:15
Complexity:279

Purity/Quality:

98% ^*data from raw suppliers

1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C1)NC3=C2C=C(C=C3)C(=O)O

Technology Process of 1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylic acid

There total 2 articles about 1,2,3,4-Tetrahydrocyclopenta[b]indole-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 4-cyclopentylidenehydrazino-benzoic acid

: 446829-40-9
1,2,3,4-tetrahydrocyclopenta[b]indole-7-carboxylic acid

Guidance literature:: With sulfuric acid; In water; for 0.25h; Heating / reflux;

Reference yield:

: 619-67-0
4-Hydrazinobenzoic acid

: 120-92-3
cyclopentanone

: 446829-40-9
1,2,3,4-tetrahydrocyclopenta[b]indole-7-carboxylic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 120 ℃;
DOI:10.1016/j.ejmech.2018.02.050

Reference yield:

: 446829-40-9
1,2,3,4-tetrahydrocyclopenta[b]indole-7-carboxylic acid

: 4-ethyl-N-(4-(ethylsulfonyl)benzyl)-1,2,3,4-tetrahydrocyclopenta[b]indole-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 2 h / 85 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 20 °C

3.1: ethanol; water / 90 °C / Alkaline conditions

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sulfuric acid; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2018.02.050