619-67-0Relevant articles and documents
Selective detection of cyanide ion in 100 % water by indolium based dual reactive binding site optical sensor
Jayasudha, Palanisamy,Manivannan, Ramalingam,Park, Jong Ho,Son, Young-A
, (2020)
The indolium based sensor (R) system was designed, synthesized, characterized and its cyanide recognizing abilities are examined in 100 % water. The sensor attach with cyanide ion through nucleophilic addition to C atom of the indolium C[dbnd]N group. Also the sensor displayed colorimetric and fluorimetric behavior and it can be simply observed by naked eye. The addition of other chosen anions does not affect the sensor response towards cyanide ion. Test strip constructed on R was act as a convenient test kit to distinguish cyanide ion. Besides, the recognizing ability of sensor has been effectively applied in real water samples and this was validated with HPLC technique. Thus the receptor can be used as an effective sensor to sense cyanide ion water.
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies
Eldeeb, Assem H.,Abo-Ashour, Mahmoud F.,Angeli, Andrea,Bonardi, Alessandro,Lasheen, Deena S.,Elrazaz, Eman Z.,Nocentini, Alessio,Gratteri, Paola,Abdel-Aziz, Hatem A.,Supuran, Claudiu T.
supporting information, (2021/05/10)
New series of benzenesulfonamide and benzoic acid derivatives were designed and synthesized using tail/dual tail approach to improve potency and selectivity as carbonic anhydrase inhibitors. The synthesized compounds evaluated as CAIs against isoforms hCA I, II, IV and IX with acetazolamide (AAZ) as standard inhibitor. The benzenesulfonamide derivatives 7a-d, 8a-h, 12a-c, 13a and 15a-c showed moderate to potent inhibitory activity with selectivity toward isoform hCA II, especially, compound 13a with (Ki = 7.6 nM), while the benzoic acid analogues 12d-f, 13b and 15d-f didn't show any activity except compounds 12d,f and 15e that showed weak activity. Additionally, molecular docking was performed for compounds 7a, 8a, 8e, 12a, 13a and 15a on isoform hCA I, II to illustrate the possible interaction with the active site to justify the inhibitory activity.
Spontaneous optical response towards cyanide ion in water by a reactive binding site probe
Jayasudha, Palanisamy,Manivannan, Ramalingam,Park, Jong Ho,Son, Young-A
supporting information, (2020/03/10)
Indolium derivatives bearing diphenyl amine (R1) and dibenzylamine (R2) linked through benzene was designed, synthesized, characterized and its cyanide recognizing abilities are studied in 100% water. The probes were exhibited dual channel properties i.e. both colorimetric and fluorimetric changes for the effective sensing of cyanide ion. The discrete color variation of probes with cyanide ion makes possible as colorimetric sensor and which was seen easily through naked eye. The recognition of cyanide ion is accomplished via the attachment of cyanide ion at the C atom of indolium C[dbnd]N group through nucleophilic addition. Also, the found detection limits of probes (nM range) were much lower than the WHO limit. Besides, the probes were effectively applied to determine cyanide ion in real water samples and thus was confirmed with HPLC method.