2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos

Base Information

• Chemical Name: 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos
• CAS No.: 1160861-59-5
• Molecular Formula: C43H61O2P
• Molecular Weight: 640.93
• Mol file: 1160861-59-5.mol

Synonyms:2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos;2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl;AdBrettPhos;Di-Ad-BrettPhos;AdBrettPhos 95%

Chemical Property of 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos

Chemical Property:

• Melting Point: 231-235°C
• PSA: 32.05000
• LogP: 11.78580

Purity/Quality:

98% ^*data from raw suppliers

2-(Di-1-adamantylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 95% AdBrettPhos ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos

There total 2 articles about 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl (1070663-76-1) + di-1-adamantylchlorophosphane (157282-19-4) → 2-(di-1-adamantylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl (1160861-59-5)

Guidance literature:

2-iodo-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl; With tert.-butyl lithium; In toluene; pentane; at -78 ℃; for 0.666667h; Inert atmosphere;

di-1-adamantylchlorophosphane; With copper(l) chloride; In toluene; pentane; at -78 - 140 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201201244

Reference yield:

1-Adamantyl bromide (768-90-1) → 2-(di-1-adamantylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl (1160861-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether / 15 h / Inert atmosphere; Reflux

1.2: 4 h / -40 °C / Inert atmosphere; Reflux

2.1: tert.-butyl lithium / toluene; pentane / 0.67 h / -78 °C / Inert atmosphere

2.2: 24 h / -78 - 140 °C / Inert atmosphere

With tert.-butyl lithium; magnesium; In diethyl ether; toluene; pentane;

DOI:10.1002/anie.201201244

Reference yield: 96.0%

bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II) (225931-80-6) + 2-(di-1-adamantylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl (1160861-59-5) → C94H134O4P2Pd2

Guidance literature:

In pentane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ol402859k

upstream raw materials:

1-Adamantyl bromide

2-iodo-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl

di-1-adamantylchlorophosphane

Downstream raw materials:

BrPd(C₆H₄CN)(P(C₁₀H₁₅)2C₆H₂(OCH₃)2C₆H₂(CH(CH₃)2)3)

Refernces