ME0328

Base Information

Chemical Name:ME0328
CAS No.:1445251-22-8
Molecular Formula:C19H19N3O2
Molecular Weight:321.37
Hs Code.:
Mol file:1445251-22-8.mol

Synonyms:ME0328;3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide;(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide

Suppliers and Price of ME0328

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ME 0328
10mg
$ 466.00

TRC
ME0328
50mg
$ 435.00

Tocris
ME0328 ≥98%(HPLC)
50
$ 681.00

Tocris
ME0328 ≥98%(HPLC)
10
$ 180.00

Sigma-Aldrich
ME0328 ≥98% (HPLC)
5mg
$ 124.00

Sigma-Aldrich
ME0328 ≥98% (HPLC)
25mg
$ 497.00

Medical Isotopes, Inc.
ME0328
50 mg
$ 925.00

DC Chemicals
ME0328 >98%
250 mg
$ 1050.00

DC Chemicals
ME0328 >98%
100 mg
$ 600.00

ChemScene
ME0328 99.34%
5mg
$ 60.00

Total 11 raw suppliers

Chemical Property of ME0328

Chemical Property:

PSA：78.60000
LogP:3.98570
Storage Temp.:room temp
Solubility.:DMSO: soluble10mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

ME 0328 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-43
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Description The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.
Uses ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.

Technology Process of ME0328

There total 3 articles about ME0328 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 5368-37-6
3-(4-oxo-3,4-dihydroquinazolin-2-yl)propionic acid

: 1445251-22-8
ME0328

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 19h;
DOI:10.1021/jm401394u

Reference yield:

: 1885-29-6
anthranilic acid nitrile

: 1445251-22-8
ME0328

Guidance literature:: Multi-step reaction with 3 steps

1: toluene

2: potassium carbonate; urea hydrogen peroxide adduct / acetone; water

3: 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 19 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; urea hydrogen peroxide adduct; potassium carbonate; diisopropyl-carbodiimide; In water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm401394u

Reference yield:

: 348152-61-4
4-[(2-cyanophenyl)amino]-4-oxobutanoic acid

: 1445251-22-8
ME0328

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; urea hydrogen peroxide adduct / acetone; water

2: 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 19 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; urea hydrogen peroxide adduct; potassium carbonate; diisopropyl-carbodiimide; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm401394u