CALPAIN INHIBITOR XI

Base Information

Chemical Name:CALPAIN INHIBITOR XI
CAS No.:145731-49-3
Molecular Formula:C19H29N3O4
Molecular Weight:363.45
Hs Code.:
Mol file:145731-49-3.mol

Synonyms:CALPAIN INHIBITOR XI;Z-L-ABU-CONH(CH2)3-MORPHOLINE

Suppliers and Price of CALPAIN INHIBITOR XI

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alfa Aesar
Calpain Inhibitor XI
5mg
$ 397.00

Alfa Aesar
Calpain Inhibitor XI
1mg
$ 102.00

Total 1 raw suppliers

Chemical Property of CALPAIN INHIBITOR XI

Chemical Property:

PKA:11.10±0.46(Predicted)
Density:1.145±0.06 g/cm3(Predicted)
Sensitive.:Light Sensitive

Purity/Quality:: Calpain Inhibitor XI ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses A cell-permeable dipeptidyl -ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2

Technology Process of CALPAIN INHIBITOR XI

There total 9 articles about CALPAIN INHIBITOR XI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 2-[1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-propyl]-[1,3]dithiolane-2-carboxylic acid ethyl ester

: 145731-49-3,160399-35-9
Cbz-Leu-D,L-Abu-CONH-(CH₂)3-morpholine

Guidance literature:: In ethanol; Ambient temperature;
DOI:10.1021/jm950541c

Reference yield:

: 2018-66-8
Z-Leu-OH

: 145731-49-3,160399-35-9
Cbz-Leu-D,L-Abu-CONH-(CH₂)3-morpholine

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N, dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / dimethylformamide / 16.5 h / Ambient temperature

2: NaOH / methanol / 3 h / Ambient temperature

3: pyridine, 4-N,N-dimethylaminopyridine / tetrahydrofuran

4: NaOEt / ethanol

5: BF₃*OEt₂ / CH₂Cl₂

6: 42 percent / ethanol / Ambient temperature

With pyridine; dmap; sodium hydroxide; boron trifluoride diethyl etherate; sodium ethanolate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950541c

Reference yield:

: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

: 145731-49-3,160399-35-9
Cbz-Leu-D,L-Abu-CONH-(CH₂)3-morpholine

Guidance literature:: Multi-step reaction with 7 steps

1: NaOH / methanol / 3 h / Ambient temperature

2: Et₃N, dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / dimethylformamide / 16.5 h / Ambient temperature

3: NaOH / methanol / 3 h / Ambient temperature

4: pyridine, 4-N,N-dimethylaminopyridine / tetrahydrofuran

5: NaOEt / ethanol

6: BF₃*OEt₂ / CH₂Cl₂

7: 42 percent / ethanol / Ambient temperature

With pyridine; dmap; sodium hydroxide; boron trifluoride diethyl etherate; sodium ethanolate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950541c