5,6-DiHETE

Base Information

Chemical Name:5,6-DiHETE
CAS No.:845673-97-4
Molecular Formula:C₂₀H₃₂O₄
Molecular Weight:336.472
Hs Code.:
Mol file:845673-97-4.mol

Synonyms:5,6-DiHETE;5,6-DiHETE Exclusive

Suppliers and Price of 5,6-DiHETE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
(±)5(6)-DiHETE ≥97%
100μg
$ 328.00

Cayman Chemical
(±)5(6)-DiHETE ≥97%
50μg
$ 173.00

Cayman Chemical
(±)5(6)-DiHETE ≥97%
25μg
$ 92.00

Total 13 raw suppliers

Chemical Property of 5,6-DiHETE

Chemical Property:

PSA：77.76000
LogP:4.15830

Purity/Quality:

99% ^*data from raw suppliers

(±)5(6)-DiHETE ≥97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Eicosapentaenoic acid (EPA; ) is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. EPA is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. The biological activity of (±)5(6)-DiHETE has not been documented.

Technology Process of 5,6-DiHETE

There total 2 articles about 5,6-DiHETE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 234087-56-0
6-[(3Z,6Z,9Z,12Z)-1-iodopentadeca-3,6,9,12-tetraen-1-yl]-tetrahydro-2H-pyran-2-one

: 845673-97-4
(8Z,11Z,14Z,17Z)-5,6-dihydroxyicosa-8,11,14,17-tetraenoic acid

Guidance literature:: With water; potassium hydroxide; In methanol; at 60 ℃; for 4h; Inert atmosphere;

Reference yield:

: 234087-57-1
Methyl (all-Z)-5,6-epoxyicosa-8,11,14,17-tetraenoate

: 845673-97-4
(8Z,11Z,14Z,17Z)-5,6-dihydroxyicosa-8,11,14,17-tetraenoic acid

Guidance literature:: Methyl (all-Z)-5,6-epoxyicosa-8,11,14,17-tetraenoate; With formic acid; acetic anhydride; at 20 ℃;

With potassium carbonate; In methanol; at 20 ℃; for 3h; Further stages.;
DOI:10.1039/b001944p

Reference yield:

: 845673-97-4
(8Z,11Z,14Z,17Z)-5,6-dihydroxyicosa-8,11,14,17-tetraenoic acid

: [(3Z,6Z,9Z,12Z,15Z)-pentadeca-3,6,9,12-tetraenyl]triphenylphosphonium bromide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate / tetrahydrofuran; H₂O / 1 h / 0 °C

2: 758 mg / NaBH₄ / methanol / 0.5 h / 0 °C

3: 88 percent / CBr₄; Ph₃P / CH₂Cl₂ / 1 h / 20 °C

4: 92 percent / acetonitrile / 20 h / 80 °C

With sodium tetrahydroborate; sodium periodate; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2005.07.074