Morpholine, 3-(fluoroMethyl)-4-(phenylMethyl)-, (3S)-

Base Information

Chemical Name:Morpholine, 3-(fluoroMethyl)-4-(phenylMethyl)-, (3S)-
CAS No.:1266238-75-8
Molecular Formula:C12H16FNO
Molecular Weight:209.264
Hs Code.:
Mol file:1266238-75-8.mol

Synonyms:Morpholine, 3-(fluoroMethyl)-4-(phenylMethyl)-, (3S)-;(3S)-3-(Fluoromethyl)-4-(phenylmethyl)morpholine

Suppliers and Price of Morpholine, 3-(fluoroMethyl)-4-(phenylMethyl)-, (3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-4-Benzyl-3-(fluoromethyl)morpholine 95+%
1g
$ 1146.00

Chemenu
(S)-4-benzyl-3-(fluoromethyl)morpholine 95%
1g
$ 1080.00

American Custom Chemicals Corporation
(S)-4-BENZYL-3-(FLUOROMETHYL)MORPHOLINE 95.00%
5MG
$ 498.76

American Custom Chemicals Corporation
(S)-4-BENZYL-3-(FLUOROMETHYL)MORPHOLINE 95.00%
250MG
$ 943.95

Alichem
(S)-4-Benzyl-3-(fluoromethyl)morpholine
1g
$ 918.72

Total 3 raw suppliers

Chemical Property of Morpholine, 3-(fluoroMethyl)-4-(phenylMethyl)-, (3S)-

Chemical Property:

Boiling Point:290.2±25.0 °C(Predicted)
PKA:5.44±0.40(Predicted)
PSA：12.47000
Density:1.082±0.06 g/cm3(Predicted)
LogP:1.79480
Storage Temp.:2-8°C

Purity/Quality:

99%+ ^*data from raw suppliers

(S)-4-Benzyl-3-(fluoromethyl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Morpholine, 3-(fluoroMethyl)-4-(phenylMethyl)-, (3S)-

There total 10 articles about Morpholine, 3-(fluoroMethyl)-4-(phenylMethyl)-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 101376-26-5
(3R)-4-benzyl-3-(hydroxymethyl)-morpholine

: 1266238-75-8,218594-80-0
(S)-4-benzyl-3-(fluoromethyl)morpholine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield: 51.0%

: 1266238-74-7
(S)-4-benzyl-5-fluoromethyl-morpholin-3-one

: 1266238-75-8,218594-80-0
(S)-4-benzyl-3-(fluoromethyl)morpholine

Guidance literature:: (S)-4-benzyl-5-fluoromethyl-morpholin-3-one; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 15h; Inert atmosphere;

With water; sodium hydroxide; In methanol; for 3h; Reflux;

Reference yield:

: 86808-09-5
N-(p-methylbenzoyl)-D-serine

: 1266238-75-8,218594-80-0
(S)-4-benzyl-3-(fluoromethyl)morpholine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice; Inert atmosphere

1.2: 5 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / Reflux

3.1: triethylamine / dichloromethane / 1 h / 0 °C

3.2: 15 h / 20 °C

4.1: hydrogen; acetic acid / palladium on carbon / 4 h / 40 °C

5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 8 h / 20 °C / Reflux

6.1: borane-THF / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

6.2: 3 h / Reflux

With borane-THF; hydrogen; sodium hydride; acetic acid; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium on carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;