Technology Process of (S)-4-benzyl-5-fluoromethyl-morpholin-3-one
There total 5 articles about (S)-4-benzyl-5-fluoromethyl-morpholin-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
dichloromethane;
at 20 ℃;
for 8h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice; Inert atmosphere
1.2: 5 h / 20 °C
2.1: borane-THF / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere
2.2: 3 h / Reflux
3.1: triethylamine / dichloromethane / 1 h / 0 °C
3.2: 15 h / 20 °C
4.1: hydrogen; acetic acid / palladium on carbon / 4 h / 40 °C
5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 8 h / 20 °C / Reflux
With
borane-THF; hydrogen; sodium hydride; acetic acid; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
palladium on carbon;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: borane-THF / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere
1.2: 3 h / Reflux
2.1: triethylamine / dichloromethane / 1 h / 0 °C
2.2: 15 h / 20 °C
3.1: hydrogen; acetic acid / palladium on carbon / 4 h / 40 °C
4.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 8 h / 20 °C / Reflux
With
borane-THF; hydrogen; acetic acid; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
palladium on carbon;
In
tetrahydrofuran; dichloromethane;
