1-Chrolo-8-Methylisoquinoline

Base Information

• Chemical Name: 1-Chrolo-8-Methylisoquinoline
• CAS No.: 174873-81-5
• Molecular Weight: 0
• Mol file: 174873-81-5.mol

Synonyms:1-Chrolo-8-Methylisoquinoline

Chemical Property of 1-Chrolo-8-Methylisoquinoline

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chrolo-8-Methylisoquinoline

There total 9 articles about 1-Chrolo-8-Methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

8-Methylisoquinolin-1(2H)-one (116409-35-9) → 1-chloro-8-methylisoquinoline (174873-81-5)

Guidance literature:

With trichlorophosphate; for 3h; Heating;

DOI:10.3987/COM-95-S60

Reference yield: 41.0%

8-methylisoquinoline N-oxide (174873-80-4) → 1-chloro-8-methylisoquinoline (174873-81-5)

Guidance literature:

With trichlorophosphate; In chloroform; for 2h; Heating;

DOI:10.1016/0957-4166(96)00107-3

Reference yield:

8-methylisoquinoline (62882-00-2) → 1-chloro-8-methylisoquinoline (174873-81-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / H₂O₂; H₂O; CH₃COOH / 12 h / 80 °C

2: 5 h / Heating

3: NaOH; H₂O / 12.67 h

4: 74 percent / POCl₃ / 3 h / Heating

With sodium hydroxide; water; dihydrogen peroxide; acetic acid; trichlorophosphate; 1: Oxidation / 2: Acetoxylation / 3: Hydrolysis / 4: Substitution;

DOI:10.1039/a905161i

upstream raw materials:

8-Methylisoquinolin-1(2H)-one

8-methylisoquinoline N-oxide

8-methylisoquinoline

(2,2-Dimethoxy-ethyl)-[1-o-tolyl-meth-(Z)-ylidene]-amine

Refernces

• 1、 Tsue, Hirohito,Fujinami, Hideyuki,Itakura, Takeshi,Tsuchiya, Ryuta,Kobayashi, Kimiko,Takahashi, Hiroki,Hirao, Ken-Ichi. "8,8′-Dialkyl-1,1′-biisoquinolines: Preparation, absolute configuration and unexpected racemization behaviour". . p. 3677 - 3683. Retrieved 2007/10/03.