1-Chloro-8-methylisoquinoline

Base Information

Chemical Name:1-Chloro-8-methylisoquinoline
CAS No.:174873-81-5
Molecular Formula:
Molecular Weight:0
Hs Code.:
European Community (EC) Number:829-679-9
DSSTox Substance ID:DTXSID40570671
Nikkaji Number:J1.248.239F
Wikidata:Q82458197

Synonyms:1-CHLORO-8-METHYLISOQUINOLINE;174873-81-5;MFCD14702550;SCHEMBL1536351;DTXSID40570671;AKOS015995900;MB13685;BS-11758;SY143826;CS-0224899;E87412;EN300-121715

Suppliers and Price of 1-Chloro-8-methylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1-Chloro-8-methylisoquinoline

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:177.0345270
Heavy Atom Count:12
Complexity:160

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(=CC=C1)C=CN=C2Cl

Technology Process of 1-Chloro-8-methylisoquinoline

There total 9 articles about 1-Chloro-8-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 116409-35-9
8-Methylisoquinolin-1(2H)-one

: 174873-81-5
1-chloro-8-methylisoquinoline

Guidance literature:: With trichlorophosphate; for 3h; Heating;
DOI:10.3987/COM-95-S60

Reference yield: 41.0%

: 174873-80-4
8-methylisoquinoline N-oxide

: 174873-81-5
1-chloro-8-methylisoquinoline

Guidance literature:: With trichlorophosphate; In chloroform; for 2h; Heating;
DOI:10.1016/0957-4166(96)00107-3

Reference yield:

: 62882-00-2
8-methylisoquinoline

: 174873-81-5
1-chloro-8-methylisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / H₂O₂; H₂O; CH₃COOH / 12 h / 80 °C

2: 5 h / Heating

3: NaOH; H₂O / 12.67 h

4: 74 percent / POCl₃ / 3 h / Heating

With sodium hydroxide; water; dihydrogen peroxide; acetic acid; trichlorophosphate; 1: Oxidation / 2: Acetoxylation / 3: Hydrolysis / 4: Substitution;
DOI:10.1039/a905161i