62882-00-2

Basic information

• Product Name: 8-METHYL-ISOQUINOLINE
• Synonyms: 8-METHYL-ISOQUINOLINE;Isoquinoline, 8-methyl-
• CAS NO: 62882-00-2
• Molecular Formula: C₁₀H₉N
• Molecular Weight: 143.18516
• EINECS: 263-747-3
• Product Categories: Isoquinoline Derivertives
• Mol File: 62882-00-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 205°C
• Boiling Point: 246.29°C (estimate)
• Flash Point: 107.7°C
• Appearance: /
• Density: 1.0584 (estimate)
• Vapor Pressure: 0.0218mmHg at 25°C
• Refractive Index: 1.6125 (estimate)
• PKA: 5?+-.0.23(Predicted)
• CAS DataBase Reference: 8-METHYL-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHYL-ISOQUINOLINE(62882-00-2)
• EPA Substance Registry System: 8-METHYL-ISOQUINOLINE(62882-00-2)

Safety Data

• Hazardous Substances Data: 62882-00-2(Hazardous Substances Data)

Usage

General Description

8-Methyl-isoquinoline is a chemical compound with the molecular formula C10H9N. It is a colorless liquid with a distinct odor and is commonly used in the synthesis of various pharmaceuticals and agrochemicals. 8-Methyl-isoquinoline is also found in some plants and has been studied for its potential antioxidant and anti-inflammatory properties. It is considered to be a versatile building block in organic chemistry and has been used in the development of novel drugs and organic materials. However, its use and production should be carefully managed due to its potential health and environmental hazards.

InChI:InChI=1/C10H9N/c1-8-3-2-4-9-5-6-11-7-10(8)9/h2-7H,1H3

Upstream product

• 7344-34-5 4-methyl-1H-indene 
• 54879-71-9 (2,2-Dimethoxy-ethyl)-[1-o-tolyl-meth-(Z)-ylidene]-amine 
• 529-20-4 2-methylphenyl aldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 
• 109245-75-2 o-methylbenzylideneaminoethanaldiethoxyacetal 
• 84900-35-6 2,4,6-Trimethyl-benzenesulfonate2-amino-8-methyl-isoquinolinium; 
• 645-36-3 2,2-diethoxy-ethanamine 

Downstream Products

• 174873-81-5 1-chloro-8-methylisoquinoline 
• 863290-51-1 1-(3,4-dimethoxy-benzyl)-8-methyl-isoquinoline 
• 863290-43-1 2-benzoyl-1-cyano-8-methyl-1,2-dihydroisoquinoline 
• 84900-35-6 2,4,6-Trimethyl-benzenesulfonate2-amino-8-methyl-isoquinolinium; 

Relevant articles and documents

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine

The synthesis and the 125I-apamin binding studies of original C-5- and C-8-substituted 1-(3,4-dimethoxy-benzyl)-2,2-dimethyl-1,2,3,4- tetrahydroisoquinoliniums and 1-(3,4-dimethoxy-benzyl)-6,6-dimethyl-4,5,6,7- tetrahydrothieno[2,3-c]pyridiniums were performed in order to find a reversible and selective SK channel blocker structurally related to N-methyl-laudanosine and N-methyl-noscapine. A bulky alkyl substituent in the C-8 position of the tetrahydroisoquinoline produces a clear increase in the affinity for the apamin sensitive binding sites. The presence of an electron-withdrawing group in the C-5 and C-8 positions is not a suitable substitution for the affinity of drugs structurally related to N-methyl-laudanosine. Thiophenic analogues and 8-methoxy derivatives possess a poor affinity for the apamin sensitive binding sites. Electrophysiological studies performed with the most effective compound showed a blockade of the apamin sensitive afterhyperpolarization in rat dopaminergic neurons.

Synthesis and resolution of 1,1-bi-8-methylisoquinoline: Formation of an optically active complex with high chiral recognition

The synthesis and resolution of 1,1-bi-8-methylisoquinoline (±)-5 is reported. An optically active palladium complex with high chiral recognition was formed during the complexation between a chiral palladium complex and the two enantiomers of (±)-5. The free energy barrier ΔGF(≠) for interconversion of enantiomers was estimated to be 97,2 KJ/mol at 40°C.