futalosine

Base Information

• Chemical Name: futalosine
• CAS No.: 210644-32-9
• Molecular Formula: C19H18N4O7
• Molecular Weight: 414.36882
• Mol file: 210644-32-9.mol

Synonyms:futalosine;3-[1,5,6-Trideoxy-1-(1,6-dihydro-6-oxo-9H-purin-9-yl)-β-D-ribo-heptofuranuronoyl]benzoic Acid

Chemical Property of futalosine

Chemical Property:

• Boiling Point: 890.2±65.0 °C(Predicted)
• PKA: 3.85±0.10(Predicted)
• PSA: 167.89000
• Density: 1.73±0.1 g/cm3(Predicted)
• LogP: 0.51240

Purity/Quality:

97% ^*data from raw suppliers

Futalosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. A new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. An antibiotic cancer inhibitor.

Technology Process of futalosine

There total 2 articles about futalosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

futalosine methyl ester (210424-87-6) → futalosine (210644-32-9)

Guidance literature:

With lithium hydroxide; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2010.10.010

Reference yield:

6-amino-6-deoxyfutalosine → futalosine (210644-32-9)

Guidance literature:

With Sav₂₅₉₅ from Steptomyces avermitilis MA-4680; water; at 30 ℃; for 16h; pH=7.5; Reagent/catalyst; Kinetics; Enzymatic reaction;

DOI:10.1021/bi400750a

upstream raw materials:

futalosine methyl ester

Refernces

• 1、 Li, Xu,Tanner, Martin E.. "An efficient synthesis of futalosine". supporting information; experimental part. p. 6463 - 6465. Retrieved 2010/12/25.