Diethyl 2-(acetylamino)-2-(3-fluoro-4,5-dimethoxybenzyl)malonate

Base Information

Chemical Name:Diethyl 2-(acetylamino)-2-(3-fluoro-4,5-dimethoxybenzyl)malonate
CAS No.:42877-14-5
Molecular Formula:C18H24FNO7
Molecular Weight:385.38
Hs Code.:2924299090
Mol file:42877-14-5.mol

Synonyms:Diethyl 2-(acetylamino)-2-(3-fluoro-4,5-dimethoxybenzyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diethyl 2-(acetylamino)-2-(3-fluoro-4,5-dimethoxybenzyl)malonate

Chemical Property:

PSA：103.65000
LogP:2.22680

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of Diethyl 2-(acetylamino)-2-(3-fluoro-4,5-dimethoxybenzyl)malonate

There total 7 articles about Diethyl 2-(acetylamino)-2-(3-fluoro-4,5-dimethoxybenzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22027-96-9
5-nitroveratral

: 42877-14-5
5-(2',2'-dicarbethoxy-2'-acetamidoethyl)-2,3-dimethoxyfluorobenzene

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NaBH₄ / tetrahydrofuran / 1 h / 40 - 60 °C

2: 93 percent / conc. HCl / 0.67 h / Heating

3: 85 percent / t-BuOK / dimethylformamide / 2 h / 120 °C

4: 99percent hydrazine hydrate / 5percent Ru/C / aq. ethanol / 24 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium tert-butylate; hydrazine hydrate; Ru-carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0022-1139(93)03032-H

Reference yield:

: 42877-11-2
3,4-dimethoxy-5-nitrobenzyl chloride

: 42877-14-5
5-(2',2'-dicarbethoxy-2'-acetamidoethyl)-2,3-dimethoxyfluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / t-BuOK / dimethylformamide / 2 h / 120 °C

2: 99percent hydrazine hydrate / 5percent Ru/C / aq. ethanol / 24 h / Heating

With potassium tert-butylate; hydrazine hydrate; Ru-carbon; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0022-1139(93)03032-H

Reference yield:

: 42877-12-3
5-(2',2'-dicarbethoxy-2'-acetamidoethyl)-2,3-dimethoxynitrobenzene

: 42877-14-5
5-(2',2'-dicarbethoxy-2'-acetamidoethyl)-2,3-dimethoxyfluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 99percent hydrazine hydrate / 5percent Ru/C / aq. ethanol / 24 h / Heating

With hydrazine hydrate; Ru-carbon; In ethanol;
DOI:10.1016/0022-1139(93)03032-H