3-FluoroMethyl-azetidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-FluoroMethyl-azetidine-1-carboxylic acid tert-butyl ester
CAS No.:1443983-85-4
Molecular Formula:C9H16FNO2
Molecular Weight:189.23
Hs Code.:
Mol file:1443983-85-4.mol

Synonyms:3-FluoroMethyl-azetidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 3-FluoroMethyl-azetidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 3-(fluoromethyl)azetidine-1-carboxylate 97%
5g
$ 1980.00

Matrix Scientific
tert-Butyl 3-(fluoromethyl)azetidine-1-carboxylate 97%
10g
$ 2880.00

Crysdot
tert-Butyl3-(fluoromethyl)azetidine-1-carboxylate 97%
10g
$ 2715.00

Crysdot
tert-Butyl3-(fluoromethyl)azetidine-1-carboxylate 97%
5g
$ 1866.00

Chemenu
tert-Butyl3-(fluoromethyl)azetidine-1-carboxylate 95+%
5g
$ 1759.00

Total 9 raw suppliers

Chemical Property of 3-FluoroMethyl-azetidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Boiling Point:232.3±5.0 °C(Predicted)
PKA:-2.25±0.40(Predicted)
PSA：29.54000
Density:1.076±0.06 g/cm3(Predicted)
LogP:1.76070

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 3-(fluoromethyl)azetidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-FluoroMethyl-azetidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 3-FluoroMethyl-azetidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 142253-57-4
3-methanesulfonyloxymethyl-azetidine-1-carboxylic acid tert-butyl ester

: 1443983-85-4
tert-butyl 3-(fluoromethyl)azetidine-1-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); at 25 - 100 ℃; for 16h; Inert atmosphere; Large scale;

Reference yield:

: 142253-56-3
3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester

: 1443983-85-4
tert-butyl 3-(fluoromethyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 65 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1443983-85-4
tert-butyl 3-(fluoromethyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 7 h / 5 - 10 °C / Large scale

1.2: 5 - 20 °C / Large scale

2.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 60 - 65 °C / Inert atmosphere; Large scale

3.1: triethylamine / dichloromethane / 5 h / 0 - 15 °C / Large scale

4.1: triethylamine tris(hydrogen fluoride); 1,8-diazabicyclo[5.4.0]undec-7-ene / 16 h / 25 - 100 °C / Inert atmosphere; Large scale

With methanol; sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; dichloromethane;