AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER

Base Information

• Chemical Name: AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
• CAS No.: 610791-05-4
• Molecular Formula: C10H17 N O4
• Molecular Weight: 215.249
• Hs Code.: 2933990090
• Mol file: 610791-05-4.mol

Synonyms:1-tert-Butyl3-methyl azetidine-1,3-dicarboxylate; Methyl 1-(tert-butoxycarbonyl)azetidine-3-carboxyloate;Methyl 1-(tert-butyloxycarbonyl)azetidine-3-carboxylate; Methyl1-tert-butoxycarbonyl-azetidine-3-carboxylate

Chemical Property of AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00743mmHg at 25°C
• Refractive Index: n20/D1.452
• Boiling Point: 269°C at 760 mmHg
• PKA: -2.97±0.40(Predicted)
• Flash Point: 116.5°C
• PSA: 55.84000
• Density: 1.072 g/mL at 25 °C
• LogP: 0.96420
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl 1-Boc-azetidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Building block used as a precursor to the synthesis of azaspiro[3.4]octanes developed in the Carreira group. This substrate can be readily functionalized via enolization at the 3-position in the presence of LDA.

Technology Process of AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER

There total 7 articles about AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid (142253-55-2) → azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (610791-05-4)

Guidance literature:

With diazomethyl-trimethyl-silane; In toluene; at 0 - 20 ℃; for 0.916667h;

Reference yield: 99.0%

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid (142253-55-2) + diazomethyl-trimethyl-silane (18107-18-1) → azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (610791-05-4)

Guidance literature:

In methanol; toluene; at 0 - 20 ℃; for 0.916667h;

Reference yield: 95.0%

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid (142253-55-2) + methyl iodide (74-88-4) → azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (610791-05-4)

Guidance literature:

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid; With sodium hydride; In tetrahydrofuran; at 10 - 20 ℃; for 0.5h;

methyl iodide; at 15 - 25 ℃; for 16h;

upstream raw materials:

methyl 3-azetidinecarboxylate hydrochloride

di-tert-butyl dicarbonate

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

tert-butyl 3-(3-amino-1H-pyrazol-5-yl)azetidine-1-carboxylate

tert-butyl 3-(2-cyanoacetyl)azetidine-1-carboxylate

1-tert-butyl 3-methyl 3-fluoroazetidine-1,3-dicarboxylate

3-fluoro-3-(hydroxymethyl)azetidin-1-carboxylic acid tert-butyl ester