Liproxstatin-1

Base Information

• Chemical Name: Liproxstatin-1
• CAS No.: 950455-15-9
• Molecular Formula: C₁₉H₂₁ClN₄
• Molecular Weight: 340.856
• Mol file: 950455-15-9.mol

Synonyms:Liproxstatin-1;N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine

Chemical Property of Liproxstatin-1

Chemical Property:

• PSA: 48.45000
• LogP: 4.00080
• Storage Temp.: -20°C
• Solubility.: Soluble in DMSO (15 mg/ml)

Purity/Quality:

99% ^*data from raw suppliers

Liproxstatin-1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by the ferroptosis-inducing agents L-buthionine sulphoximine (BSO), erastin , and (1S,3R)-RSL3 in a concentration-dependent manner in MEFs, but does not inhibit necroptosis, apoptosis, or necrosis. It inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in human renal proximal tubule epithelial cells. Liproxstatin-1 (10 mg/kg) increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice and reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury. It is also an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals.
• Uses: Liproxstatin-1 has been used as a cell death inhibitor in the cell viability assay and for the determination of lipid peroxidation.

Technology Process of Liproxstatin-1

There total 1 articles about Liproxstatin-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ liproxstatin-1 (950455-15-9)

Guidance literature:

In methanol; at 50 ℃; for 4h;

With chloro-trimethyl-silane; In methanol; acetonitrile; at 50 - 60 ℃; for 4h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Refernces