2,4-Diiodooxazole

Base Information

• Chemical Name: 2,4-Diiodooxazole
• CAS No.: 1037597-73-1
• Molecular Formula: C3HI2NO
• Molecular Weight: 320.85508
• Hs Code.: 2934999090
• Mol file: 1037597-73-1.mol

Synonyms:2,4-Diiodooxazole;2,4-Diiodooxazole 97%

Chemical Property of 2,4-Diiodooxazole

Chemical Property:

• Melting Point: 98-103℃
• PSA: 26.03000
• LogP: 1.88380
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Diiodooxazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Diiodooxazole

There total 1 articles about 2,4-Diiodooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxazol (288-42-6) → 2,4-di-iodo-oxazole (1037597-73-1)

Guidance literature:

oxazol; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

With iodine; In tetrahydrofuran; at -78 - 20 ℃; for 144h; Inert atmosphere;

Reference yield: 64.0%

2,4-di-iodo-oxazole (1037597-73-1) + phenylboronic acid (98-80-6) → 2,4-diphenyl-1,3-oxazole (838-41-5) + 4-iodooxazole (1224742-18-0) + 2-iodo-4-phenyl-1,3-oxazole (1210372-47-6) + 4-iodo-2-phenyl-1,3-oxazole (1210372-46-5)

Guidance literature:

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 60 ℃; for 8h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo100148x

Reference yield: 62.0%

2,4-di-iodo-oxazole (1037597-73-1) + 3-acetylphenylboronic acid → 1-[3-(2-iodo-1,3-oxazol-4-yl)phenyl]ethanone (1210372-52-3) + 1-[3-(4-iodo-1,3-oxazol-2-yl)phenyl]ethanone + C19H15NO3

Guidance literature:

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 60 ℃; for 6h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo100148x

upstream raw materials:

oxazol

Downstream raw materials:

4-iodo-2-(4-methoxyphenyl)oxazole

2-iodo-4-(4-methoxyphenyl)oxazole

2,4-bis(4-methoxyphenyl)oxazole

2-(3-fluorophenyl)-4-iodo-1,3-oxazole

Refernces