5-bromo-4-chloro-2-methylaniline

Base Information

• Chemical Name: 5-bromo-4-chloro-2-methylaniline
• CAS No.: 1126367-88-1
• Molecular Formula: C7H7BrClN
• Molecular Weight: 220.496
• Hs Code.: 2921430090
• Mol file: 1126367-88-1.mol

Synonyms:5-bromo-4-chloro-2-methylaniline;BenzenaMine, 5-broMo-4-chloro-2-Methyl-;5-bromo-4-chloro-2-methylbenzenamine

Chemical Property of 5-bromo-4-chloro-2-methylaniline

Chemical Property:

• PSA: 26.02000
• LogP: 3.57430
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-4-chloro-2-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-4-chloro-2-methylaniline

There total 2 articles about 5-bromo-4-chloro-2-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-bromo-2-chloro-4-methyl-5-nitrobenzene (1126367-34-7) → 5-bromo-4-chloro-2-methylaniline (1126367-88-1)

Guidance literature:

1-bromo-2-chloro-4-methyl-5-nitrobenzene; FeCl₃ adsorbed on SiO₂; In methanol; at 70 ℃; for 0.25h;

With hydrazine; In methanol; water; Heating / reflux;

Reference yield:

1-bromo-2-chloro-4-methylbenzene (6627-51-6) → 5-bromo-4-chloro-2-methylaniline (1126367-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 0.08 h / -20 °C

2: hydrogenchloride; potassium carbonate; iron / tetrahydrofuran; ethyl acetate / 0.5 h / 60 °C

With hydrogenchloride; sulfuric acid; nitric acid; iron; potassium carbonate; In tetrahydrofuran; ethyl acetate;

Reference yield:

5-bromo-4-chloro-2-methylaniline (1126367-88-1) + 4-(pyridin-2-ylmethoxy)benzoyl chloride (1126601-99-7) → N-(5-bromo-4-chloro-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide (1126369-57-0)

Guidance literature:

With pyridine; triethylamine; In dichloromethane; at 50 ℃; for 2h;

upstream raw materials:

1-bromo-2-chloro-4-methyl-5-nitrobenzene

1-bromo-2-chloro-4-methylbenzene

Downstream raw materials:

N-(5-bromo-4-chloro-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide

N-(4-chloro-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-(pyridin-2-ylmethoxy)benzamide

N-[4-chloro-5-(1H-imidazol-2-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

N-[4-chloro-2-methyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide