para-TOPOLIN RIBOSIDE(pTR)

Base Information

• Chemical Name: para-TOPOLIN RIBOSIDE(pTR)
• CAS No.: 23666-24-2
• Molecular Formula: C18H21N5O5
• Molecular Weight: 387.395
• Mol file: 23666-24-2.mol

Synonyms:para-TOPOLIN RIBOSIDE(pTR);N-(4-Methoxybenzyl)-adenosine;N6-(4-Methoxybenzyl)adenosine

Chemical Property of para-TOPOLIN RIBOSIDE(pTR)

Chemical Property:

• Melting Point: 154-156℃
• PSA: 134.78000
• LogP: 0.13150
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

N6-(4-Methoxybenzyl)adenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: para-Topolin Riboside can be used as reagent/reactant for synthetic preparation and cytotoxicity of platinum complexes with hydroxy-, methoxy-, fluoro- and chloro-substituted N-benzyladenosine ligands as anti-tumor agents.

Technology Process of para-TOPOLIN RIBOSIDE(pTR)

There total 3 articles about para-TOPOLIN RIBOSIDE(pTR) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-Chloropurine riboside (2004-06-0) + 4-methoxy-benzylamine (2393-23-9) → (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((4-methoxybenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol (23666-24-2)

Guidance literature:

With triethylamine; In butan-1-ol; at -5 - 90 ℃;

DOI:10.3390/molecules18066990

Reference yield: 89.0%

4-methoxy-benzylamine (2393-23-9) + Inosine (58-63-9) → (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((4-methoxybenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol (23666-24-2)

Guidance literature:

With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; at 140 ℃; for 36h;

DOI:10.1080/15257779408012148

Reference yield:

→ (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((4-methoxybenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol (23666-24-2)

Guidance literature:

Aus entspr. 6-Cl-triacetat u /BRN= 508206/;

upstream raw materials:

4-methoxy-benzylamine

Inosine

6-Chloropurine riboside

Downstream raw materials:

adenosine

C₂₁H₂₅N₅O₅

C₂₅H₂₈N₆O₆S

C₂₈H₃₂N₆O₆S