4-Methoxybenzylamine

Base Information

• Chemical Name: 4-Methoxybenzylamine
• CAS No.: 2393-23-9
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 29222900
• NSC Number: 9269
• UNII: 2M6QLM4NWE
• DSSTox Substance ID: DTXSID2062371
• Nikkaji Number: J101.237A
• Wikidata: Q27121634
• ChEMBL ID: CHEMBL12720
• Mol file: 2393-23-9.mol

Synonyms:4-methoxybenzylamine;p-methoxybenzylamine

Chemical Property of 4-Methoxybenzylamine

Chemical Property:

• Appearance/Colour: clear colorless to slightly yellow liquid
• Vapor Pressure: 0.0472mmHg at 25°C
• Melting Point: -10 °C
• Refractive Index: n20/D 1.546(lit.)
• Boiling Point: 236.499 °C at 760 mmHg
• PKA: 9.30±0.10(Predicted)
• Flash Point: 98.8 °C
• PSA: 35.25000
• Density: 1.028 g/cm³
• LogP: 1.85420
• Storage Temp.: Store below +30°C.
• Sensitive.: Air Sensitive
• Water Solubility.: It is highly soluble in water.
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

98% ^*data from raw suppliers

4-Methoxybenzenemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-37-22
• Safety Statements: 26-36/37/39-45-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aromatic
• Canonical SMILES: COC1=CC=C(C=C1)CN
• Uses: 4-Methoxybenzylamine is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff. It is also used fine chemical intemediate.

Technology Process of 4-Methoxybenzylamine

There total 86 articles about 4-Methoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxybenzonitrile (874-90-8) → 4-methoxy-benzylamine (2393-23-9)

Guidance literature:

With hydrogen; aluminum oxide; silica gel; nickel; In methanol; ammonia; at 120 ℃; for 6h; under 7600 Torr;

DOI:10.1055/s-2001-17481

Reference yield: 97.0%

4-methoxy-benzaldehyde (123-11-5) → 4-methoxy-benzylamine (2393-23-9)

Guidance literature:

With nickel(II) tetrafluoroborate hexahydrate; ammonia; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine; In 2,2,2-trifluoroethanol; at 100 ℃; for 24h; chemoselective reaction;

DOI:10.1039/d0sc01084g

Reference yield: 91.0%

N-(2-(4-methoxyphenyl)-2-oxoethyl)picolinamide (77250-70-5) → 4-methoxy-benzylamine (2393-23-9)

Guidance literature:

N-(2-(4-methoxyphenyl)-2-oxoethyl)picolinamide; With hydrogenchloride; In water; at 20 ℃; for 0.0833333h; Inert atmosphere;

With zinc; In water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.05.068

upstream raw materials:

p-methoxyl benzaldoxime

4-methoxyphenylacetamide

hexamethylenetetramine

p-methoxybenzyl chloride

Downstream raw materials:

N-(4-methoxybenzyl)pyrimidin-2-amine

(4-methoxy-benzyl)-(6-methyl-pyridazin-3-yl)-amine

pyrazine-2-carboxylic acid-(4-methoxy-benzylamide)

2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione

Refernces

Total synthesis of leopolic acid A, a natural 2,3-pyrrolidinedione with antimicrobial activity

10.3762/bjoc.12.159

The research focuses on the first total synthesis of leopolic acid A, a natural 2,3-pyrrolidinedione with antimicrobial activity derived from a fungal metabolite. The purpose of the study was to design and execute a synthetic strategy for leopolic acid A, which could potentially lead to the development of new antimicrobial compounds given the growing concern over antibiotic resistance. The synthesis involved crucial steps such as a Dieckmann cyclization to form the 2,3-pyrrolidinedione ring and a Wittig olefination to introduce the polymethylene chain. Key chemicals used in the process included p-methoxybenzylamine, diethyl oxalate, BnBr, K2CO3, DIBAL-H, PPh3, CBr4, n-nonanal, LiHMDS, CAN, and 2-tert-butoxycarbonylamino-3-methylbutyric acid pentafluorophenyl ester, among others. The study concluded that leopolic acid A was successfully synthesized in an 11-step process, despite the instability of several intermediates containing the 2,3-pyrrolidinedione moiety. The synthesized compounds showed antibacterial activity, suggesting their potential as promising candidates for future development in the fight against antibiotic resistance. The research also paved the way for further synthesis of analogues to build a structure–activity relationship profile and optimize the activity.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 2393-23-9 4-Methoxybenzylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send