5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-β-D-ribofuanosyl)-1H-benziMidazole

Base Information

• Chemical Name: 5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-β-D-ribofuanosyl)-1H-benziMidazole
• CAS No.: 443678-71-5
• Molecular Formula: C₁₈H₁₈Cl₂N₂O₇
• Molecular Weight: 445.256
• Mol file: 443678-71-5.mol

Synonyms:5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-β-D-ribofuanosyl)-1H-benziMidazole;5,6-Dichloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-benziMidazole

Chemical Property of 5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-β-D-ribofuanosyl)-1H-benziMidazole

Chemical Property:

• PSA: 105.95000
• LogP: 2.66700

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-b-D-ribofuanosyl)-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-β-D-ribofuanosyl)-1H-benziMidazole can be used as a protected inhibitor of RNA synthesis (causes premature termination of transcription).

Technology Process of 5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-β-D-ribofuanosyl)-1H-benziMidazole

There total 5 articles about 5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-β-D-ribofuanosyl)-1H-benziMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C18H18Cl2N2O7S → (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)tetrahydrofuran-3,4-diyl diacetate (108126-17-6,443678-71-5)

Guidance literature:

With rose bengal; water; oxygen; sodium chloride; In N,N-dimethyl-formamide; at 25 ℃; for 48h; Irradiation; Green chemistry;

DOI:10.1039/d0gc02269a

Reference yield: 79.0%

5,6-dichlorobenzimidazole (6478-73-5) + 1,2,3,5-tetra-O-acetyl-β-L-ribofuranose (144490-03-9) → 5,6-dichloro-1-(2,3,5-tri-O-acetyl-β-L-ribofuranosyl)benzimidazole (176299-73-3,443678-71-5)

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 2h; Heating;

DOI:10.1080/15257770008032999

Reference yield: 59.0%

5,6-dichlorobenzimidazole (6478-73-5) + 1,2,3,5-tetraacetylribose (13035-61-5) → (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)tetrahydrofuran-3,4-diyl diacetate (108126-17-6,443678-71-5)

Guidance literature:

With silica gel; Further Variations:; Reagents; microwave irradiation; Product distribution; Heating;

DOI:10.1081/NCN-120006532

upstream raw materials:

5,6-dichlorobenzimidazole

1,2,3,5-tetraacetylribose

4,5-Dichloro-1,2-phenylenediamine

1,2,3,5-tetra-O-acetyl-β-L-ribofuranose

Downstream raw materials:

5,6-dichloro-1-β-D-ribobenzimidazole

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