6478-73-5

Basic information

• Product Name: 5,6-DICHLOROBENZIMIDAZOLE
• Synonyms: BUTTPARK 121\15-71;5,6-DICHLORO-1H-1,3-BENZIMIDAZOLE;5,6-DICHLORO-1H-BENZIMIDAZOLE;5,6-DICHLORO-1H-BENZO[D]IMIDAZOLE;5,6-DICHLOROBENZIMIDAZOLE;1H-BENZIMIDAZOLE, 5,6-DICHLORO-;NSC 326397;NSC 6393
• CAS NO: 6478-73-5
• Molecular Formula: C₇H₄Cl₂N₂
• Molecular Weight: 187.03
• Product Categories: BENZIMIDAZOLE;pharmacetical;Imidazol&Benzimidazole;Aromatics Compounds;Aromatics;Heterocycles;Inhibitors
• Mol File: 6478-73-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 205-206°
• Boiling Point: 426.9°C at 760 mmHg
• Flash Point: 244.6°C
• Appearance: /
• Density: 1.571g/cm³
• Vapor Pressure: 4.24E-07mmHg at 25°C
• Refractive Index: 1.708
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.74±0.30(Predicted)
• CAS DataBase Reference: 5,6-DICHLOROBENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DICHLOROBENZIMIDAZOLE(6478-73-5)
• EPA Substance Registry System: 5,6-DICHLOROBENZIMIDAZOLE(6478-73-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 6478-73-5(Hazardous Substances Data)

Usage

Chemical Properties

Purple Solid

Uses

Different sources of media describe the Uses of 6478-73-5 differently. You can refer to the following data:
1. A benzimidazole derivative as potent inhibitor of milk xanthine oxidase.
2. A benzimidazole derivative as potent inhibitor of milk xanthine oxidase

InChI:InChI=1/C7H4Cl2N2/c8-4-1-6-7(2-5(4)9)11-3-10-6/h1-3H,(H,10,11)

Upstream product

• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 

Downstream Products

• 268549-39-9 5,6-dichloro-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)benzimidazole 
• 846541-91-1 1-(5,6-dichloro-benzimidazol-1-ylmethyl)-2,2-dimethyl-propyl 4-nitrophenyl carbonate 
• 960001-06-3 methyl 3-(((1R)-1-(2-chloro-3-hydroxyphenyl)ethyl)oxy)-5-(5,6-dichloro-1H-benzimidazol-1-yl)-2-thiophenecarboxylate 
• 176299-73-3 5,6-dichloro-1-(2,3,5-tri-O-acetyl-β-L-ribofuranosyl)benzimidazole 
• 317824-84-3 2-[(S)-1-Phenylethylamino]-4-[5,6-dichlorobenzimidazol-1-yl]pyrimidine 
• 137016-65-0 1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2-(4-nitrophenyl)ethyl triethylammonium phosphate> 

Relevant articles and documents

One-Pot Transformation of Lignin and Lignin Model Compounds into Benzimidazoles

It is a challenging task to simultaneously achieve selective depolymerization and valorization of lignin due to their complex structure and relatively stable bonds. We herein report an efficient depolymerization strategy that employs 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as oxidant/catalyst to selectively convert different oxidized lignin models to a wide variety of 2-phenylbenzimidazole-based compounds in up to 94 % yields, by reacting with o-phenylenediamines with varied substituents. This method could take full advantage of both Cβ and/or Cγ atom in lignin structure to furnish the desirable products instead of forming byproducts, thus exhibiting high atom economy. Furthermore, this strategy can effectively transform both the oxidized hardwood (birch) and softwood (pine) lignin into the corresponding degradation products in up to 45 wt% and 30 wt%, respectively. Through a “one-pot” process, we have successfully realized the oxidation/depolymerization/valorization of natural birch lignin at the same time and produced the benzimidazole derivatives in up to 67 wt% total yields.