(2,6-DIFLUORO-PHENYL)-ACETYL CHLORIDE

Base Information

• Chemical Name: (2,6-DIFLUORO-PHENYL)-ACETYL CHLORIDE
• CAS No.: 116622-90-3
• Molecular Formula: C8H5ClF2O
• Molecular Weight: 190.577
• Hs Code.: 2916399090
• Mol file: 116622-90-3.mol

Synonyms:(2,6-DIFLUORO-PHENYL)-ACETYL CHLORIDE

Chemical Property of (2,6-DIFLUORO-PHENYL)-ACETYL CHLORIDE

Chemical Property:

• PSA: 17.07000
• LogP: 2.27270

Purity/Quality:

99% ^*data from raw suppliers

2,6-DIFLUOROPHENYLACETYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2,6-DIFLUORO-PHENYL)-ACETYL CHLORIDE

There total 2 articles about (2,6-DIFLUORO-PHENYL)-ACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

2,6-difluorophenylacetic acid (85068-28-6) → 2-(2,6-difluorophenyl)acetyl chloride (116622-90-3)

Guidance literature:

With thionyl chloride; for 1.5h; Reflux;

DOI:10.1002/asia.201100089

Reference yield:

1-ethoxy-2-(2,6-difluorophenyl)-1-(N-methylimino)-ethane + oxalamic acid hydrazide (515-96-8) + 2,6-difluorophenylacetic acid (85068-28-6) → 2-(2,6-difluorophenyl)acetyl chloride (116622-90-3)

Guidance literature:

With hydrogenchloride; In 4-methyl-morpholine; thionyl chloride; ethanol; dichloromethane; water;

Reference yield: 97.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-(2,6-difluorophenyl)acetyl chloride (116622-90-3) → 1-diazo-3-(2,6-difluorophenyl)propan-2-one

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1002/asia.201100089

upstream raw materials:

oxalamic acid hydrazide

2,6-difluorophenylacetic acid

Downstream raw materials:

1-bromo-3-(2,6-difluorophenyl)propan-2-one

ethyl 4-(2,6-difluorophenyl)-3-oxobutanoate