methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate

Base Information

Chemical Name:methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate
CAS No.:1414378-14-5
Molecular Formula:C19H13Cl2F4NO3S
Molecular Weight:482.283
Hs Code.:
Mol file:1414378-14-5.mol

Synonyms:methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate

Suppliers and Price of methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 6 raw suppliers

Chemical Property of methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate

Chemical Property:

Boiling Point:566.1±60.0 °C(Predicted)
PSA：76.13000
Density:1 +-.0.1 g/cm3(Predicted)
LogP:5.48710

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate

There total 11 articles about methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414378-03-2
3-[3-(3,5-dichloro-4-fluoro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylic acid methyl ester

: 1414378-14-5
3-[5-(3,5-dichloro-4-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylic acid methyl ester

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 7148-07-4
1-pyrrolidinocyclopent-1-ene

: 1414378-14-5
3-[5-(3,5-dichloro-4-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / toluene / Reflux

2.1: water; acetic acid / tetrahydrofuran / 48 h / 20 °C

3.1: tetrachloromethane; tributylphosphine / 60 °C

3.2: -10 - 0 °C

4.1: manganese(IV) oxide / dichloromethane / 2 h / Reflux

5.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

6.1: thionyl chloride; pyridine / dichloromethane / 3 h / 20 °C

7.1: hydroxylamine hydrochloride; sodium hydroxide / water; tetrahydrofuran / 20 °C

With pyridine; tetrachloromethane; manganese(IV) oxide; thionyl chloride; tributylphosphine; hydroxylamine hydrochloride; water; acetic acid; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 3008-40-0
cyclopentane-1,2-dione

: 1414378-14-5
3-[5-(3,5-dichloro-4-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: thionyl chloride; pyridine / dichloromethane / 3 h / 20 °C

4.1: hydroxylamine hydrochloride; sodium hydroxide / water; tetrahydrofuran / 20 °C

With pyridine; thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;