Oxifungin hydrochloride

Base Information

• Chemical Name: Oxifungin hydrochloride
• CAS No.: 55242-74-5
• Molecular Formula: C13H13ClN4O
• Molecular Weight: 276.725
• Hs Code.: 2933990090
• Mol file: 55242-74-5.mol

Synonyms:Oxifungin HCl;Oxifungin hydrochloride;

Chemical Property of Oxifungin hydrochloride

Chemical Property:

• Vapor Pressure: 3.78E-08mmHg at 25°C
• Boiling Point: 446°Cat760mmHg
• Flash Point: 223.5°C
• PSA: 66.59000
• Density: g/cm³
• LogP: 3.22920

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antifungal.

Technology Process of Oxifungin hydrochloride

There total 6 articles about Oxifungin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → 1,2-Dihydro-3-phenoxymethyl-pyrido<3,4-e>as-triazin-Hydrochlorid (55242-74-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

2: 77 percent / N₂H₄*H₂O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h

3: tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

4: H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

5: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h

With hydrogenchloride; phosphorus pentachloride; hydrogen; hydrazine hydrate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00131a010

Reference yield:

pyridin-4-ol (626-64-2,157061-69-3) → 1,2-Dihydro-3-phenoxymethyl-pyrido<3,4-e>as-triazin-Hydrochlorid (55242-74-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 72 percent / HNO₃, H₂SO₄, SO₃ / 1 h / Heating

2: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

3: 77 percent / N₂H₄*H₂O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h

4: tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

5: H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

6: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h

With hydrogenchloride; phosphorus pentachloride; sulfuric acid; sulfur trioxide; hydrogen; nitric acid; hydrazine hydrate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00131a010

Reference yield:

4-hydrazino-3-nitropyridine (33544-42-2) → 1,2-Dihydro-3-phenoxymethyl-pyrido<3,4-e>as-triazin-Hydrochlorid (55242-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

2: H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

3: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00131a010

upstream raw materials:

pyridin-4-ol

4-hydrazino-3-nitropyridine

4-hydroxy-3-nitropyridine

4-chloro-3-nitropyridine

Downstream raw materials:

3-phenoxymethyl-pyrido[3,4-e][1,2,4]triazine