3-Bromo-5-(2-methoxyethoxy)pyridine

Base Information

• Chemical Name: 3-Bromo-5-(2-methoxyethoxy)pyridine
• CAS No.: 181585-07-9
• Molecular Formula: C8H10BrNO2
• Molecular Weight: 232.077
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60444764
• Mol file: 181585-07-9.mol

Synonyms:3-bromo-5-(2-methoxyethoxy)pyridine;181585-07-9;SCHEMBL428322;DTXSID60444764;JJLCNEOPNGKTQE-UHFFFAOYSA-N;MFCD19674031;AKOS013527452;3-Bromo-5-(2-methoxy-ethoxy)-pyridine;5-Bromo-3-(2-methoxy-ethoxy)-pyridine;AS-48207;CS-0194329;F19756;J-511953

Chemical Property of 3-Bromo-5-(2-methoxyethoxy)pyridine

Chemical Property:

• PSA: 31.35000
• LogP: 1.86930
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 230.98949
• Heavy Atom Count: 12
• Complexity: 124

Purity/Quality:

≥95% ^*data from raw suppliers

3-Bromo-5-(2-methoxyethoxy)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOC1=CC(=CN=C1)Br

Technology Process of 3-Bromo-5-(2-methoxyethoxy)pyridine

There total 3 articles about 3-Bromo-5-(2-methoxyethoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3,5-dibromopyridine (625-92-3) + 2-methoxy-ethanol (109-86-4,95507-80-5) → 3-bromo-5-(2-methoxyethoxy)pyridine (181585-07-9)

Guidance literature:

With sodium; at 120 ℃; for 48h; Inert atmosphere;

DOI:10.1039/c1cc12946e

Reference yield: 75.0%

5-bromopyridine-3-ol (74115-13-2) + 2-Bromoethyl methyl ether (6482-24-2) → 3-bromo-5-(2-methoxyethoxy)pyridine (181585-07-9)

Guidance literature:

5-bromopyridine-3-ol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

2-Bromoethyl methyl ether; In N,N-dimethyl-formamide; for 4h;

Reference yield:

3,5-dibromopyridine (625-92-3) → 3-bromo-5-(2-methoxyethoxy)pyridine (181585-07-9)

Guidance literature:

2-methoxy-ethanol; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

3,5-dibromopyridine; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

upstream raw materials:

3,5-dibromopyridine

2-methoxy-ethanol

5-bromopyridine-3-ol

2-Bromoethyl methyl ether

Downstream raw materials:

5-(2-methoxyethoxy)-3-pyridineboronic acid pinacol ester

1,4-bis(5-(2-methoxyethoxy)-pyridine-3-yl)benzene

C₂₁H₂₃F₂N₅O₄S