3-Bromo-5-hydroxypyridine

Base Information

• Chemical Name: 3-Bromo-5-hydroxypyridine
• CAS No.: 74115-13-2
• Molecular Formula: C5H4BrNO
• Molecular Weight: 173.997
• Hs Code.: 29339900
• European Community (EC) Number: 627-764-3
• DSSTox Substance ID: DTXSID40344793
• Nikkaji Number: J847.262I
• Wikidata: Q72457011
• Mol file: 74115-13-2.mol

Synonyms:3-Bromo-5-hydroxypyridine;74115-13-2;5-bromopyridin-3-ol;5-Bromo-3-pyridinol;5-Bromo-3-hydroxypyridine;5-Bromo-pyridin-3-ol;3-Pyridinol, 5-bromo-;MFCD00661305;3-Bromo-5-pyridinol;Pyridine, 3-ol-5-bromo-;3-HYDROXY-5-BROMOPYRIDINE;5-bromopyrid-3-ol;5-bromopyridine-3-ol;5-bromanylpyridin-3-ol;5-Bromo-3-pyridinol #;3-Hydro-5-bromo-pyridin;5-Bromo-3-hydroxylpyridine;SCHEMBL7676;3-bromo-5-hydroxy pyridine;5-bromo-3-hydroxy-pyridine;Pyridine, 3-hydroxy-5-bromo-;DTXSID40344793;3-Bromo-5-hydroxypyridine, 97%;BBL102908;RB1128;STL556717;AKOS000275939;AC-3094;CS-W019637;PB30658;PS-6098;SY003815;A9519;AM20061477;B3969;FT-0615178;EN300-75258;A838021;AC-907/30002047;J-517196;Z1172207821

Chemical Property of 3-Bromo-5-hydroxypyridine

Chemical Property:

• Appearance/Colour: light yellow needles
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 167-168 °C
• Refractive Index: 1.614
• Boiling Point: 343.68 °C at 760 mmHg
• PKA: 8.37±0.10(Predicted)
• Flash Point: 161.652 °C
• PSA: 33.12000
• Density: 1.789 g/cm³
• LogP: 1.54970
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Slightly soluble in water. Soluble in chloroform and ethyl acetate.
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.94763
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

99.00% ^*data from raw suppliers

3-Bromo-5-hydroxypyridine >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-20/21/22
• Safety Statements: 26-36/37/39-37-36-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC=C1Br)O

Technology Process of 3-Bromo-5-hydroxypyridine

There total 11 articles about 3-Bromo-5-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-amino-5-bromopyridine (13535-01-8) → 5-bromopyridine-3-ol (74115-13-2)

Guidance literature:

With sulfuric acid; sodium nitrite;

Reference yield: 89.0%

3-(benzyloxy)-5-bromopyridine (130722-95-1) → 5-bromopyridine-3-ol (74115-13-2)

Guidance literature:

3-(benzyloxy)-5-bromopyridine; With hydrogen bromide; In acetic acid; at 20 ℃; for 16h;

With ammonia; In methanol; water; at 20 ℃; for 12h;

Reference yield: 89.0%

ammonium hydroxide (1336-21-6) + 3-(benzyloxy)-5-bromopyridine (130722-95-1) → 5-bromopyridine-3-ol (74115-13-2)

Guidance literature:

In methanol; hydrogen bromide; acetic acid;

upstream raw materials:

3,5-dibromopyridine

3-amino-5-bromopyridine

5-bromo-3-ethoxypyridine

3-Bromo-5-(4-methoxy-benzyloxy)-pyridine

Downstream raw materials:

3-amino-5-hydroxypyridine

5-hydroxypyridine-3-carbonitrile

3-bromo-5-isopropoxypyridine

(S)-2-(5-bromo-pyridin-3-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 Lucas, Simon,Negri, Matthias,Heim, Ralf,Zimmer, Christina,Hartmann, Rolf W.. "Fine-tuning the selectivity of aldosterone synthase inhibitors: Structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1- ij ]quinolin-4-one derivatives". scheme or table. p. 2307 - 2319. Retrieved 2011/06/20.
• 2、 -. "ANDROGEN MODULATORS". Page/Page column 28. . Retrieved 2009/07/17.