MELAGATRAN

Base Information

• Chemical Name: MELAGATRAN
• CAS No.: 162694-63-5
• Molecular Weight: 429.51
• Mol file: 162694-63-5.mol

Synonyms:Glycine, N-[2-[2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-

Chemical Property of MELAGATRAN

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MELAGATRAN

There total 14 articles about MELAGATRAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyanobenzyl bromide (17201-43-3) → melagatran (162694-63-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 96 percent / NaH / tetrahydrofuran / 18 h / Ambient temperature

2: 93 percent / NaOH / tetrahydrofuran; methanol

3: H₂S, Et₃N / pyridine

4: acetone / 2 h / Heating

5: 94 percent / NH₄OAc / methanol / 6 h / Heating

6: 4N NaOH / tetrahydrofuran / Ambient temperature

7: 100 percent / HCl / ethyl acetate

With hydrogenchloride; sodium hydroxide; hydrogen sulfide; ammonium acetate; sodium hydride; triethylamine; In tetrahydrofuran; pyridine; methanol; ethyl acetate; acetone;

DOI:10.1080/00397919808004477

Reference yield:

tert-butyl ((tert-butoxycarbonyl)(4-cyanobenzyl)amino)-methanoate (172348-74-2) → melagatran (162694-63-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 93 percent / NaOH / tetrahydrofuran; methanol

2: H₂S, Et₃N / pyridine

3: acetone / 2 h / Heating

4: 94 percent / NH₄OAc / methanol / 6 h / Heating

5: 4N NaOH / tetrahydrofuran / Ambient temperature

6: 100 percent / HCl / ethyl acetate

With hydrogenchloride; sodium hydroxide; hydrogen sulfide; ammonium acetate; triethylamine; In tetrahydrofuran; pyridine; methanol; ethyl acetate; acetone;

DOI:10.1080/00397919808004477

Reference yield:

4-amidinobenzyl azide (162698-08-0) → melagatran (162694-63-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / H₂ / Pd/C / methanol; CHCl₃ / 24 h / Ambient temperature

2: Et₃N / tetrahydrofuran; H₂O

3: 4N NaOH / tetrahydrofuran / Ambient temperature

4: 100 percent / HCl / ethyl acetate

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water; ethyl acetate;

DOI:10.1080/00397919808004477

upstream raw materials:

(S)-1-(t-butoxycarbonyl)azetidine-2-carboxylic acid

(2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid

[(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid benzyl ester dihydrochloride

Benzyl bromoacetate