2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine

Base Information

• Chemical Name: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine
• CAS No.: 1004282-76-1
• Molecular Formula: C11H14F3N
• Molecular Weight: 217.2307696
• Hs Code.: 2921499090
• Mol file: 1004282-76-1.mol

Synonyms:2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine

Chemical Property of 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine

Chemical Property:

• PSA: 26.02000
• LogP: 3.64200

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-2-[4-(trifluoromethyl)-phenyl]propan-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine

There total 2 articles about 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-(4-(trifluoromethyl)phenyl)propanenitrile (32445-87-7) → 2-methyl-2-(4-trifluoromethyl-phenyl)-propylamine (1004282-76-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00307

Reference yield:

→ 2-methyl-2-(4-trifluoromethyl-phenyl)-propylamine (1004282-76-1)

Guidance literature:

Reference yield:

2-methyl-2-(4-trifluoromethyl-phenyl)-propylamine (1004282-76-1) + chloroformic acid ethyl ester (541-41-3) → [2-methyl-2-(4-trifluoromethyl-phenyl)-propyl]-carbamic acid ethyl ester (1365760-26-4)

Guidance literature:

With sodium carbonate; In chloroform; at 0 ℃; for 1h;

upstream raw materials:

2-methyl-2-(4-(trifluoromethyl)phenyl)propanenitrile

Downstream raw materials:

[2-methyl-2-(4-trifluoromethyl-phenyl)-propyl]-carbamic acid ethyl ester

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