2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-5-CARBALDEHYDE

Base Information

• Chemical Name: 2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-5-CARBALDEHYDE
• CAS No.: 38002-92-5
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Hs Code.: 2932999099
• Mol file: 38002-92-5.mol

Synonyms:AKOS MSC-0774;2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-5-CARBALDEHYDE;2,2-DIMETHYL-2,3-DIHYDRO-1-BENZOFURAN-5-CARBALDEHYDE;5-benzofurancarboxaldehyde, 2,3-dihydro-2,2-dimethyl-;2,2-dimethyl-2,3-dihydro-1-benzofuran-5-carbaldehyde(SALTDATA: FREE)

Chemical Property of 2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-5-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 278.342°C at 760 mmHg
• Flash Point: 121.77°C
• PSA: 26.30000
• Density: 1.104g/cm³
• LogP: 2.21260
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2,2-dimethyl-2,3-dihydro-1-benzofuran-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-5-CARBALDEHYDE

There total 5 articles about 2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-5-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 5-Bromo-2,2-dimethyl-2,3-dihydrobenzo[b]furan (5337-94-0) → 2,3-dihydro-2,2-dimethylbenzofuran-5-carboxaldehyde (38002-92-5)

Guidance literature:

5-Bromo-2,2-dimethyl-2,3-dihydrobenzo[b]furan; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmc.2009.04.010

Reference yield:

4-hydroxy-3-(2-methyl-2-propenyl)benzaldehyde → 2,3-dihydro-2,2-dimethylbenzofuran-5-carboxaldehyde (38002-92-5)

Guidance literature:

With sodium bicarbonate; In ethyl acetate; toluene;

Reference yield:

4-bromo-2-(2’-methylallyl)phenol (1165738-86-2) → 2,3-dihydro-2,2-dimethylbenzofuran-5-carboxaldehyde (38002-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine / dichloromethane / 12 h / 20 °C

2.1: tert.-butyl lithium / hexane / -78 - 0 °C

2.2: 0.5 h / 0 °C

With iodine; tert.-butyl lithium; In hexane; dichloromethane;

upstream raw materials:

N,N-dimethyl-formamide

5-Bromo-2,2-dimethyl-2,3-dihydrobenzo[b]furan

4-bromo-2-(2’-methylallyl)phenol

4-bromo-phenol

Downstream raw materials:

N-cyclohexyl-N-((2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)-methyl)-3,4-dimethoxybenzenesulfonamide

N-cyclopentyl-N-((2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)methyl)-3,4-dimethoxybenzenesulfonamide

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