2-Amino-4-(aminosulfonyl)benzenecarboxylic acid

Base Information

• Chemical Name: 2-Amino-4-(aminosulfonyl)benzenecarboxylic acid
• CAS No.: 25096-72-4
• Molecular Formula: C7H8N2O4S
• Molecular Weight: 216.218
• Hs Code.: 2935009090
• Mol file: 25096-72-4.mol

Synonyms:2-Amino-4-(aminosulfonyl)benzenecarboxylic acid;2-Amino-4-(aminosulfonyl)benzoic acid

Chemical Property of 2-Amino-4-(aminosulfonyl)benzenecarboxylic acid

Chemical Property:

• Vapor Pressure: 2.71E-11mmHg at 25°C
• Boiling Point: 511.6°C at 760 mmHg
• Flash Point: 263.2°C
• PSA: 131.86000
• Density: 1.623g/cm³
• LogP: 1.97670

Purity/Quality:

98%min ^*data from raw suppliers

2-amino-4-sulfamoylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4-(aminosulfonyl)benzenecarboxylic acid

There total 7 articles about 2-Amino-4-(aminosulfonyl)benzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-methyl-3-nitrobenzenesulfonamide (6949-23-1) → 2-amino-4-sulfamoyl-benzoic acid (25096-72-4)

Guidance literature:

With selenium; nitrobenzene; sodium hydroxide; In methanol; water; dimethyl sulfoxide; at 90 ℃; for 5h; Inert atmosphere;

DOI:10.1039/d0gc04407e

Reference yield:

2-nitro-4-sulfamoyl-benzoic acid (29092-31-7) → 2-amino-4-sulfamoyl-benzoic acid (25096-72-4)

Guidance literature:

With ammonium sulfide;

Reference yield:

→ 2-amino-4-sulfamoyl-benzoic acid (25096-72-4)

Guidance literature:

With potassium permanganate; anschliessende Reduktion mit Hilfe von Eisen;

upstream raw materials:

2-nitro-4-sulfamoyl-benzoic acid

4-methyl-3-nitrobenzenesulfonamide

4-chlorosulfonyl-2-nitro-benzoic acid

4-chlorosulfonyl-2-nitro-benzoyl chloride

Downstream raw materials:

2-(2-benzo[1,3]dioxol-5-yl-acetylamino)-4-sulfamoyl-benzoic acid

Refernces

• 1、 JACKMAN,PETROW,STEPHENSON,WILD. "Studies inthe field of diuretic agents. VIII. Some miscellaneous derivatives.". . p. 202 - 211. Retrieved 2007/10/05.