6949-23-1

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYL-3-NITROBENZENESULFONAMIDE is used as an intermediate for the preparation of α-keto amide inhibitors of hepatitis C virus NS3 protease. These inhibitors play a significant role in the development of antiviral drugs targeting the hepatitis C virus, contributing to the treatment and management of the disease.
Additionally, 4-METHYL-3-NITROBENZENESULFONAMIDE is used to synthesize 1,4-diazepane-3,5-dione derivatives. These derivatives have potential applications in the prevention and treatment of various diseases associated with chymase, an enzyme involved in inflammatory processes and other physiological functions. By targeting chymase, these derivatives can help in the development of therapeutic agents for conditions such as asthma, allergic rhinitis, and other inflammatory diseases.

InChI:InChI=1/C7H8N2O4S/c1-5-2-3-6(14(8,12)13)4-7(5)9(10)11/h2-4H,1H3,(H2,8,12,13)

Upstream product

• 54090-41-4 2-nitro-p-toluenesulfonyl chloride 
• 616-83-1 4-methyl-3-nitrobenzenesulfonyl chloride 
• 877-99-6 1-methoxy-4-(2-methyl-1-propenyl)benzene 
• 120893-18-7 4-methyl-3-nitrobenzenesulfonyl azide 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 99170-74-8 3-Nitro-4-methyl-benzolsulfonyl-isopropylamid 
• 4694-12-6 2,4,4-trimethylcyclopentan-1-one 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 29092-31-7 2-nitro-4-sulfamoyl-benzoic acid 
• 54090-41-4 2-nitro-p-toluenesulfonyl chloride 
• 25096-72-4 2-amino-4-sulfamoyl-benzoic acid 
• 6274-28-8 3-amino-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

TGF-beta receptor inhibitor

The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compound shown as the formula (I) of the present invention is useful as a TGF-beta receptor inhibitor, particularly a TGF beta RI inhibitor, for example, in the prevention or treatment of various TGF beta RI (ALK5) mediated related diseases.

Novel N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides with periodic acid catalyzed by chromium(III) acetate hydroxide

Chromium(III) acetate hydroxide has been found to be an efficient catalyst for N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides to furnish sulfonamides in good to excellent yields with periodic acid in acetonitrile at room temperature.

REACTION OF ORGANIC AZIDES WITH UNSATURATED COMPOUNDS XI. REARRANGEMENTS OF BICYCLIC TRIAZOLINES, OBTAINED FROM TAUTOMERIC 2,4,4-TRIMETHYL-AND 3,3,5-TRIMETHYL-1-METHOXYCYCLOPENTENES AND 4-METHYL-3-NITROBENZENESULFONYL AZIDE

The reaction of 4-methyl-3-nitrobenzenesulfonyl azide with the tautomeric 2,4,4-trimethyl- and 3,3,5-trimethyl-1-methoxycyclopentenes leads to the formation of the products from transformation of both triazolines in almost equal ratios.The less substituted triazoline is converted through the corresponding aziridine into the allylsulfonamide, while the more substituted triazoline rearranges preferentially to methyl N-arylsulfonyl-1,3,3-trimethylcyclobutanecarboximidate.

REACTION OF ORGANIC AZIDES WITH UNSATURATED COMPOUNDS. VIII. REARRANGEMENT OF Δ2-1,2,3-TRIAZOLINES, OBTAINED FROM ARENESULFONYL AZIDES AND β,β-DIMETHYL-4-METHOXYSTYRENE BY AN ARYL SHIFT

2-Methyl-2-propanal was found in the products from the reaction of arenesulfonyl azides with β,β-dimethyl-4-methoxystyrene after hydrolysis.This indicates that 1-arylsulfonyl-4,4-dimethyl-5--Δ2-1,2,3-triazolenes rearrange by an aryl and not a hydride shift.