3-(2-Aminoethyl)benzene-1,2-diol

Base Information

• Chemical Name: 3-(2-Aminoethyl)benzene-1,2-diol
• CAS No.: 579-59-9
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.18
• Hs Code.: 2922299090
• Mol file: 579-59-9.mol

Synonyms:3-(2-Aminoethyl)benzene-1,2-diol

Chemical Property of 3-(2-Aminoethyl)benzene-1,2-diol

Chemical Property:

• PSA: 66.48000
• LogP: 1.29930

Purity/Quality:

≥99% ^*data from raw suppliers

2,3-Dihydroxyphenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Dihydroxyphenethylamine is a useful chemical compound for syntehsis of 1-(Aminomethyl)-1,2,3,4-tetrahydroisoquinolines.

Technology Process of 3-(2-Aminoethyl)benzene-1,2-diol

There total 7 articles about 3-(2-Aminoethyl)benzene-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethyoxybenzaldehyde (86-51-1) → 2,3-Dihydroxy-phenyl-ethylamin (579-59-9)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂, FeCl₃ / PtO₂ / ethanol

2: SOCl₂

3: H₂O

4: LiAlH₄

5: aq. HCl / 160 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; hydrogen; iron(III) chloride; platinum(IV) oxide; In ethanol; water;

DOI:10.1021/ja01076a043

Reference yield:

2,3-dimethoxyphenethylamine (3213-29-4) → 2,3-Dihydroxy-phenyl-ethylamin (579-59-9)

Guidance literature:

With hydrogenchloride; at 160 ℃;

DOI:10.1021/ja01076a043

Reference yield:

2,3-dimethoxybenzyl alcohol (5653-67-8) → 2,3-Dihydroxy-phenyl-ethylamin (579-59-9)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂

2: H₂O

3: LiAlH₄

4: aq. HCl / 160 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; In water;

DOI:10.1021/ja01076a043

upstream raw materials:

2,3-dimethoxyphenethylamine

2-(2,3-bis-benzyloxyphenyl)ethylamine

2-(2-amino-ethyl)-6-methoxy-phenol; hydrochloride

2,3-dimethoxybenzyl alcohol

Refernces