2,3-Dimethoxybenzaldehyde

Base Information

• Chemical Name: 2,3-Dimethoxybenzaldehyde
• CAS No.: 86-51-1
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 29124900
• European Community (EC) Number: 201-677-7
• NSC Number: 403661,51953,6314
• UNII: 8ALP3SY00L
• DSSTox Substance ID: DTXSID80235333
• Nikkaji Number: J96.722J
• Wikidata: Q27270112
• ChEMBL ID: CHEMBL3039102
• Mol file: 86-51-1.mol

Synonyms:2,3-Dimethoxybenzaldehyde;86-51-1;o-Veratraldehyde;Benzaldehyde, 2,3-dimethoxy-;MFCD00003309;EINECS 201-677-7;5,6-Dimethoxybenzaldehyde;NSC 403661;8ALP3SY00L;2,3-Dimethoxybenzaldehyde-d6;AI3-00141;NSC-6314;NSC-51953;NSC-403661;Benzaldehyde,3-dimethoxy-;2,3-Dimethoxy-benzaldehyde;dimethoxybenzaldehyde;UPCMLD00WStructure66;2,3-dimethoxybenzaldehyd;Spectrum2_001964;2,3 dimethoxybenzaldehyde;VERATRALDEHYDE, O-;2,3-Dimethoxy-benzaldehyd;UNII-8ALP3SY00L;2, 3 dimethoxybenzaldehyde;BIDD:ER0646;SCHEMBL319070;SPBio_002087;CHEMBL3039102;DTXSID80235333;NSC6314;2,3-Dimethoxybenzaldehyde, 98%;BCP10425;CS-M3620;NSC51953;BBL008737;CCG-39482;NSC403661;s4778;STK498192;AKOS000118970;AC-24169;AS-11994;BP-11464;HY-41407;LS-25014;SY003539;AM20060739;D0625;FT-0601053;2-Hydroxy-3-methoxybenzaldehyde, methyl ether;EN300-19139;A841692;W-104065;Q27270112;F2190-0611;Z104472922

Chemical Property of 2,3-Dimethoxybenzaldehyde

Chemical Property:

• Appearance/Colour: white to brown crystalline powder
• Vapor Pressure: 0.00849mmHg at 25°C
• Melting Point: 48-52 °C(lit.)
• Refractive Index: 1.534
• Boiling Point: 266.7 °C at 760 mmHg
• Flash Point: 105.8 °C
• PSA: 35.53000
• Density: 1.114 g/cm³
• LogP: 1.51630
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive
• Solubility.: Solubility in methanol with almost transparency.
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dimethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Benzaldehydes
• Canonical SMILES: COC1=CC=CC(=C1OC)C=O
• Uses: A benzaldehyde derivative that may possess antifungal activity of redox-active benzaldehydes that target cellular antioxidation. It could function as chemosensitizing agents in concert with convention al drugs or fungicides to improve antifungal efficacy. 2,3-Dimethoxybenzaldehyde possess antifungal activity of redox-active benzaldehydes that target cellular antioxidation. It could function as chemosensitizing agents in concert with conventional drugs to improve antifungal efficacy.

Technology Process of 2,3-Dimethoxybenzaldehyde

There total 35 articles about 2,3-Dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + methyl iodide (74-88-4) → 2,3-dimethyoxybenzaldehyde (86-51-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 45 ℃; for 42h;

DOI:10.1021/om3001372

Reference yield: 99.0%

2,3-dimethoxybenzyl alcohol (5653-67-8) → 2,3-dimethyoxybenzaldehyde (86-51-1)

Guidance literature:

With aluminium trichloride; 1-decyl-4-aza-1-azoniabicyclo[2.2.2]octane chlorochromate; In acetonitrile; for 1.4h; Heating;

DOI:10.1134/S1070428006060054

Reference yield: 98.7%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + dimethyl sulfate (77-78-1) → 2,3-dimethyoxybenzaldehyde (86-51-1)

Guidance literature:

With potassium carbonate; In benzene;

DOI:10.1016/S0009-3084(02)00125-1

upstream raw materials:

2-(2,3-dimethoxyphenyl)-2-hydroxyacetonitrile

1,2-dimethoxy-3-((1E)-prop-1-en-1-yl)benzene

3-methoxy-2-hydroxybenzaldehyde

dimethyl sulfate

Downstream raw materials:

(Z)-2(2,3-dimethoxybenzylidene)benzofuran-3(2H)-one

2-(2,3-dimethoxy-trans-styryl)-6-methoxy-quinolin-4-ol

2,3-dimethoxycinnamic acid

2,3-dimethoxy-benzaldehyde-(2,4-dinitro-phenylhydrazone)

Refernces

• 1、 Dogga, Bhushanarao,Joseph, Jayan T.,Kumar, C. S. Ananda. "Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source". supporting information. p. 309 - 313. Retrieved 2020/12/23.
• 2、 -. "SUBSTITUTED-PYRIDINYL COMPOUNDS AND USES THEREOF". Page/Page column 91. . Retrieved 2020/01/10.