4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid benzyl ester
• CAS No.: 196601-12-4
• Molecular Formula: C₂₀H₂₃NO₅S
• Molecular Weight: 389.472
• Hs Code.: 2933399090
• Mol file: 196601-12-4.mol

Synonyms:4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid benzyl ester;Benzyl 4-(tosyloxy)piperidine-1-carboxylate;Benzyl4-{[(4-methylbenzene)sulfonyl]oxy}piperidine-1-carboxylate;1-Cbz-4-(tosyloxy)piperidine

Chemical Property of 4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid benzyl ester

Chemical Property:

• Boiling Point: 548.9±50.0 °C(Predicted)
• PKA: -3.02±0.40(Predicted)
• PSA: 81.29000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 4.52020

Purity/Quality:

97% ^*data from raw suppliers

Benzyl 4-{[(4-methylbenzene)sulfonyl]oxy}piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid benzyl ester

There total 1 articles about 4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5) + p-toluenesulfonyl chloride (98-59-9) → benzyl 4-(tosyloxy)piperidine-1-carboxylate (196601-12-4)

Guidance literature:

With pyridine; at 20 ℃; for 23h;

Reference yield:

benzyl 4-(tosyloxy)piperidine-1-carboxylate (196601-12-4) → (S)-benzyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(4-fluorophenyl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 90 °C

2: copper; copper(II) sulfate / tetrahydrofuran / 16 h

With sodium azide; copper; copper(II) sulfate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

benzyl 4-(tosyloxy)piperidine-1-carboxylate (196601-12-4) → (S)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl)amino)quinoline-3-carbonitrile trifluoroacetate

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 90 °C

2: copper; copper(II) sulfate / tetrahydrofuran / 16 h

3: palladium 10% on activated carbon; hydrogen; acetaldehyde / ethyl acetate / 2.5 h / 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; copper; copper(II) sulfate; acetaldehyde; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

1-(benzyloxycarbonyl)-4-hydroxypiperidine

p-toluenesulfonyl chloride

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