Benzyl 4-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: Benzyl 4-hydroxypiperidine-1-carboxylate
• CAS No.: 95798-23-5
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Hs Code.: 2933399090
• European Community (EC) Number: 628-802-1
• DSSTox Substance ID: DTXSID60383265
• Nikkaji Number: J1.018.975F
• Wikidata: Q72441348
• Mol file: 95798-23-5.mol

Synonyms:95798-23-5;benzyl 4-hydroxypiperidine-1-carboxylate;Benzyl 4-hydroxy-1-piperidinecarboxylate;1-CBZ-4-HYDROXYPIPERIDINE;N-benzyloxycarbonyl-4-hydroxypiperidine;1-Piperidinecarboxylic acid, 4-hydroxy-, phenylmethyl ester;BENZYL 4-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;MFCD01863722;(phenylmethyl) 4-oxidanylpiperidine-1-carboxylate;N-Cbz-4-hydroxy-1-piperidine;N-CBZ-4-HYDROXYPIPERIDINE;1-Cbz-4-piperidinol;4-hydroxy-N-CBZ-piperidine;SCHEMBL77639;1-Carbobenzoxy-4-piperidinol;1-carbobenzyloxypiperidin-4-ol;4-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;DTXSID60383265;1-(Carbobenzyloxy)piperidin-4-ol;JKIUUDJOCYHIGY-UHFFFAOYSA-N;1-benzyloxycarbonylpiperidine-4-ol;1-Carbobenzoxy-4-hydroxypiperidine;N-benzyloxycarbonyl piperidin-4-ol;BCP12930;1-(Benzyloxycarbonyl)piperidin-4-ol;AB6216;AM1228;1-(Benzyloxycarbonyl)piperidine-4-ol;AKOS009157555;1-benzyloxycarbonyl-4-hydroxypiperidine;benzyl 4hydroxy-1-piperidinecarboxylate;CS-W008246;MB02152;N-benzyloxycarbonyl 4-hydroxypiperidine;PS-6154;N-benzyloxycarbonyl-4-hydroxy-piperidine;benzyl 4-hydroxypiperidine-2-carboxylate;1-(benzyloxycarbonyl)-4-hydroxypiperidine;4-hydroxy-N-(benzyloxycarbonyl)piperidine;AC-16354;benzyl 4-hydroxy-1-piperidine carboxylate;SY010998;B4869;FT-0622808;EN300-69989;phenylmethyl 4-hydroxy-1-piperidinecarboxylate;Benzyl 4-hydroxy-1-piperidinecarboxylate, 97%;phenylmethyl 4-hydroxy-1-piperidine carboxylate;4-Hydroxy-1-piperidinecarboxylic Acid Benzyl Ester;benzyl 4-hydroxytetrahydro-1(2H)pyridinecarboxylate;J-519809;Z352927960;B0G

Chemical Property of Benzyl 4-hydroxypiperidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 1.3E-06mmHg at 25°C
• Refractive Index: n20/D 1.543(lit.)
• Boiling Point: 384.942 °C at 760 mmHg
• PKA: 14.79±0.20(Predicted)
• Flash Point: 186.606 °C
• PSA: 49.77000
• Density: 1.22 g/cm³
• LogP: 1.71780
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 235.12084340
• Heavy Atom Count: 17
• Complexity: 243

Purity/Quality:

97% ^*data from raw suppliers

Benzyl4-Hydroxypiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1O)C(=O)OCC2=CC=CC=C2
• Uses: Reactant for synthesis of: Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation Piperidine derivatives Molecular rods Oxazolidinone-quinolone hybrids and their antibacterial activity Cyclic prodrug of RGD peptidomimeticReactant for oxidation of alcohols

Technology Process of Benzyl 4-hydroxypiperidine-1-carboxylate

There total 19 articles about Benzyl 4-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

Reference yield: 99.0%

4-HYDROXYPIPERIDINE (5382-16-1) + benzyl chloroformate (501-53-1,94274-21-2) → 1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5)

Guidance literature:

4-HYDROXYPIPERIDINE; benzyl chloroformate; With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 0.5h;

With hydrogenchloride; In 1,4-dioxane; water; pH=2;

Reference yield: 97.0%

4-(tert-butyldimethylsilyloxy)piperidine-1-carboxylic acid benzyl ester (97231-85-1) → 1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2005.10.043

upstream raw materials:

4-HYDROXYPIPERIDINE

phenyl chloroacetate

benzyl chloroformate

1-benzyloxycarbonyl-1,2,3,6-tetrahydropyridine

Downstream raw materials:

t-Butyl 2-(1-benzyloxycarbonyl-4-piperidyl)oxyacetate

benzyl 4-oxo-1-piperidinecarboxylate

4-(acetylthio)-1-(benzyloxycarbonyl)piperidine

4-benzyloxy-N-(benzyloxycarbonyl)piperidine