CarbaMiMidothioic Acid 9-Hydroxynonyl Ester MonobroMide

Base Information

• Chemical Name: CarbaMiMidothioic Acid 9-Hydroxynonyl Ester MonobroMide
• CAS No.: 511545-93-0
• Molecular Formula: C10H23BrN2OS
• Molecular Weight: 299.275
• Mol file: 511545-93-0.mol

Synonyms:CarbaMiMidothioic Acid 9-Hydroxynonyl Ester BroMide;CarbaMiMidothioic Acid 9-Hydroxynonyl Ester MonobroMide

Chemical Property of CarbaMiMidothioic Acid 9-Hydroxynonyl Ester MonobroMide

Chemical Property:

• Solubility.: Dimethyl Sulfoxide, Methanol

Purity/Quality:

99.9% ^*data from raw suppliers

CarbamimidothioicAcid9-HydroxynonylEsterBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CarbaMiMidothioic Acid 9-Hydroxynonyl Ester MonobroMide is used in the preparation of Fulvestrant intermediates.

Technology Process of CarbaMiMidothioic Acid 9-Hydroxynonyl Ester MonobroMide

There total 2 articles about CarbaMiMidothioic Acid 9-Hydroxynonyl Ester MonobroMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,9-Nonanediol (3937-56-2) → 2-(9-hydroxynonyl)-2-thiopseudourea hydrobromide (511545-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide / water; toluene / 7 h / Reflux; Large scale reaction

2: isopropyl alcohol; toluene / 20 h / Reflux; Large scale reaction

With hydrogen bromide; In water; isopropyl alcohol; toluene;

DOI:10.1021/op900315j

Reference yield:

9-bromononan-1-ol (55362-80-6) + thiourea (17356-08-0) → 2-(9-hydroxynonyl)-2-thiopseudourea hydrobromide (511545-93-0)

Guidance literature:

In isopropyl alcohol; toluene; for 20h; Reflux; Large scale reaction;

DOI:10.1021/op900315j

Reference yield:

2-(9-hydroxynonyl)-2-thiopseudourea hydrobromide (511545-93-0) → 1-bromo-9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonane (148757-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; acetonitrile / 83 h / 40 - 72 °C / Inert atmosphere; Large scale reaction

2: bromine; triphenylphosphine / acetonitrile / 3 h / 23 °C / Large scale reaction

With bromine; triphenylphosphine; sodium hydroxide; In water; acetonitrile;

DOI:10.1021/op900315j

upstream raw materials:

9-bromononan-1-ol

thiourea

1,9-Nonanediol

Downstream raw materials:

9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl alcohol

1-bromo-9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonane

3-oxo-7α-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-4-en-17βyl acetate

3-oxo-7β-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-4-en-17βyl acetate