148757-89-5

Usage

Uses

1. Used in Pharmaceutical Industry:
1-BROMO-9-[(4,4,5,5,5-PENTAFLUOROPENTYL)THIO]-NONANE is used as a reagent for the preparation of androgen, which is a hormone that plays a crucial role in the development and maintenance of male characteristics. The compound is particularly useful in the treatment of advanced prostate cancer, where androgen therapy can help manage the disease and alleviate symptoms.
2. Used in Chemical Synthesis:
In addition to its pharmaceutical applications, 1-BROMO-9-[(4,4,5,5,5-PENTAFLUOROPENTYL)THIO]-NONANE can also be utilized in chemical synthesis processes. Its unique molecular structure allows it to serve as a building block or intermediate in the production of other complex organic compounds, potentially leading to the development of new materials and products across various industries.
3. Used in Research and Development:
The compound's distinctive properties make it an interesting subject for research and development in the fields of chemistry and materials science. Scientists and researchers can explore its potential applications in creating new compounds, understanding its interactions with other molecules, and investigating its possible uses in various technological applications.

Upstream product

• 252947-01-6 1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane 
• 511545-93-0 2-(9-hydroxynonyl)-2-thiopseudourea hydrobromide 
• 511545-94-1 9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl alcohol 
• 55362-80-6 9-bromononan-1-ol 
• 3937-56-2 1,9-Nonanediol 
• 148043-73-6 4,4,5,5,5-pentafluorpentan-1-ol 
• 4549-33-1 1,9-Dibromononane 
• 148757-88-4 4,4,5,5,5-pentafluoropentane-1-thiol 
• 89359-54-6 9-bromo-1-nonene 
• 13038-21-6 non-8-en-1-ol 
• 4286-55-9 1-bromo-6-hexanol 
• 629-11-8 1,6-hexanediol 

Downstream Products

• 415927-29-6 3-oxo-7α-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-4-en-17βyl acetate 
• 1239977-74-2 3-oxo-7β-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-4-en-17βyl acetate 
• 511545-94-1 9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl alcohol 

Relevant academic research and scientific papers

Sulfur-containing compound based on glutaryl imide skeleton and application of compound

The present disclosure relates to compound shown in a formula (I) or salts, solvates, isotope-enriched analogs, tautomers, polymorphs, stereoisomers, or mixtures of stereoisomers of the compound, andthe application thereof in the treatment of tumours. The present disclosure also provides tumor treatment application of the compound showed in a formula (I') or pharmaceutically acceptable salts, solvates, isotope-enriched analogs, tautomers, polymorphic substances, stereoisomers, or mixtures of stereoisomers of the compound.

PROCESS AND INTERMEDIADES FOR THE PREPARATION OF 7-ALKYLATED STEROIDS

A process for preparing compounds of formula (I), or a salt, solvate or stereoisomer thereof, including Fulvestrant, which process comprises free radical to a compound of formula (III), or a salt, solvate or stereoisomer thereof. The invention also refers to intermediates of said process.

Fulvestrant: From the laboratory to commercial-scale manufacture

The development of a commercial manufacturing process for fulvestrant (the active ingredient in 'Faslodex') is described. Key steps in the synthesis are stereoselective 1,6-addition of an organocuprate to a steroidal dienone followed by copper-mediated aromatisation of the A-ring. The strategy for dealing with noncrystalline intermediates is outlined. The production of drug substance of acceptable quality is critically dependent on limiting the formation of key impurities. The origin of these impurities is discussed, and measures to prevent or control their formation are described.

11β-substituted 14,17-ethanoestratrienes, process for their production and their use as pharmaceutical agents

The invention relates to 11 β-substituted 14,17-ethanoestratrienes of the general formula 1 STR1 where R 1, R 2 and R 3 are defined in the specification. The compound have antiestrogenic activity and are, therefore, useful for the treatment of estrogen dependent disorders.