Dichloro-4-methoxyphenylphosphine

Base Information

• Chemical Name: Dichloro-4-methoxyphenylphosphine
• CAS No.: 19909-85-4
• Molecular Formula: C7H7Cl2OP
• Molecular Weight: 209.012
• DSSTox Substance ID: DTXSID60382733
• Nikkaji Number: J307.734I
• Wikidata: Q82174125
• Mol file: 19909-85-4.mol

Synonyms:dichloro-4-methoxyphenylphosphine;19909-85-4;Dichloro-(4-methoxyphenyl)phosphane;4-methoxyphenyldichlorophosphine;SCHEMBL2202134;DTXSID60382733;AKOS032949277;1-(Dichlorophosphino)-4-methoxybenzene;Phosphonous dichloride, (4-methoxyphenyl)-

Chemical Property of Dichloro-4-methoxyphenylphosphine

Chemical Property:

• PSA: 22.82000
• LogP: 3.11000
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 207.9611572
• Heavy Atom Count: 11
• Complexity: 113

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)P(Cl)Cl

Technology Process of Dichloro-4-methoxyphenylphosphine

There total 4 articles about Dichloro-4-methoxyphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methoxybenzene (100-66-3) → dichloro-4-methoxyphenylphosphine (19909-85-4)

Guidance literature:

With bismuth(III) chloride; phosphorus trichloride; for 2.5h; Heating; further reagents;

DOI:10.1016/S0040-4020(98)00601-2

Reference yield:

4-methoxyphenylzinc chloride (93296-09-4) → dichloro-4-methoxyphenylphosphine (19909-85-4)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; at -78 - 20 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.1c01560

Reference yield:

bis(p-anisyl)mercury (2097-72-5) → dichloro-4-methoxyphenylphosphine (19909-85-4)

Guidance literature:

With phosphorus trichloride; at 180 - 200 ℃;

upstream raw materials:

bis(p-anisyl)mercury

methoxybenzene

4-methoxyphenylzinc chloride

Downstream raw materials:

di(n-butyl)(p-methoxyphenyl)phosphine

(4-methoxy-phenyl)-phosphonous acid diethyl ester

(diethyl)-(p-methoxyphenyl)phosphine

(4-methoxy-phenyl)-dipropyl-phosphine

Refernces

• 1、 Kirst, Christin,Tietze, Jonathan,Ebeling, Marian,Horndasch, Lukas,Karaghiosoff, Konstantin. "The Formation of P-C Bonds Utilizing Organozinc Reagents for the Synthesis of Aryl- A nd Heteroaryl-Dichlorophosphines". . p. 17337 - 17343. Retrieved 2021/11/18.
• 2、 Hall, C. Dennis,Tweedy, Bruce R.,Lowther, Nicholas. "The kinetics and mechanism of the reaction of tricoordinate phosphorus compounds with sulfenate esters". . p. 341 - 358. Retrieved 2007/10/03.